Parkinson disease (PD) is the second most common neurodegenerative movement
disorder. Pharmacological animal models are invaluable tools to study the pathological …

Parkinson's disease (PD) is a neurodegenerative disorder, classically considered a
movement disorder. A great deal is known about the anatomical connections and …

Despite the different animal models of Parkinson's disease developed during the last years,
they still present limitations modelling the slow and progressive process of …

Parkinson's disease (PD) is a multifactorial disease with a complex etiology that results from
genetic risk factors, environmental exposures and most likely a combination of both. Rodent …

The hallmark of Parkinson Disease (PD) is the degeneration of dopaminergic neurons in the
substantia nigra pars compacta (SNc) and the consequent striatal dopamine (DA) …

Parkinson's disease (PD) is a complex genetic disorder that is associated with
environmental risk factors and aging. Vertebrate genetic models, especially mice, have …

Nonhuman primate (NHP) models of Parkinson's disease (PD) play an essential role in the
understanding of PD pathophysiology and the assessment of PD therapies. NHP research …

Publisher Summary Animal models are an essential tool to study human diseases, not only
to enable a thorough investigation into the mechanisms involved in the pathogenesis of a …

Rodent models and molecular tools, mainly omics and RNA interference, have been
rigorously used to decode the intangible etiology and pathogenesis of Parkinson's disease …

Neurological disorders in humans can be modeled in animals using standardized
procedures that recreate specific pathogenic events and their behavioral outcomes. The …