Background: Melanoma patients stop responding to targeted therapies mainly due to
mitogen activated protein kinase (MAPK) pathway re-activation, phosphoinositide 3 …

Celecoxib has been found to be effective in cancer prevention and treatment. Its
combination with other chemotherapeutic agents was reported to produce …

Melanoma is a highly drug resistant cancer. To circumvent this problem, a class of
synergistically acting drug combinations, which inhibit multiple key pathways in melanoma …

Despite the broad prevention programs and early detection and therapy progress,
melanoma of skin is still responsible for 0.6% of deaths caused by tumour disease. Every …

With a constantly increasing incidence, cutaneous melanoma has raised the need for a
better understanding of its complex microenvironment that may further guide therapeutic …

Melanoma is a highly metastatic and deadly disease. An agent simultaneously targeting the
COX-2, PI3K/Akt, and mitogen-activated protein kinase (MAPK) signaling pathways that are …

Background Metastatic malignant melanoma is one of the most aggressive malignancies
and its treatment remains challenging. Recent studies demonstrate that the melanoma …

Malignant melanoma is a highly aggressive form of skin cancer which has a propensity for
metastasis. Epithelial mesenchymal transition (EMT) plays a primordial role in the …

Abstract Inhibitors of cyclooxygenase 2 (COX 2) and the mammalian target of rapamycin
(mTOR) show direct and indirect antitumor effects in a variety of cancers. This study was …

Using multiple drugs to kill cancer cells can decrease drug resistance development.
However, this approach is frequently limited by the bioavailability and toxicity of the …