Chromium supplementation enhances insulin signalling in skeletal muscle of obese KK/HlJ diabetic mice

WY Chen, CJ Chen, CH Liu… - Diabetes, Obesity and …, 2009 - Wiley Online Library
Aim: Chromium is an essential nutrient required for glucose and lipid metabolism.
Laboratory and clinical evidences indicate that chromium supplementation may improve …

[HTML][HTML] Chromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR: LA-cp rats

ZQ Wang, XH Zhang, JC Russell, M Hulver… - The Journal of …, 2006 - Elsevier
Chromium is one of the few trace minerals for which a specific cellular mechanism of action
has not been identified. Recent in vitro studies suggest that chromium supplementation may …

Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice

N Sreejayan, F Dong, MR Kandadi, X Yang, J Ren - Obesity, 2008 - Wiley Online Library
Objective: Chromium has gained popularity as a nutritional supplement for diabetic patients.
This study evaluated the effect of chronic administration of a chromium complex of d …

Molecular mechanisms of chromium in alleviating insulin resistance

Y Hua, S Clark, J Ren, N Sreejayan - The Journal of nutritional …, 2012 - Elsevier
Type 2 diabetes is often associated with obesity, dyslipidemia and cardiovascular anomalies
and is a major health problem approaching global epidemic proportions. Insulin resistance …

Cellular chromium enhances activation of insulin receptor kinase

H Wang, A Kruszewski, DL Brautigan - Biochemistry, 2005 - ACS Publications
Chromium has been recognized for decades as a nutritional factor that improves glucose
tolerance by enhancing in vivo insulin action, but the molecular mechanism is unknown …

Evaluation of insulin binding and signaling activity of newly synthesized chromium (III) complexes in vitro

P Mackowiak, Z Krejpcio, M Sassek… - Molecular …, 2010 - spandidos-publications.com
In the present study, the influence of chromium (III) complexes (acetate, chloride, glycinate,
histidinate, lactate and propionate) on insulin binding and signal transduction …

Effect of chromium and zinc on insulin signaling in skeletal muscle cells

ER Miranda, CS Dey - Biological trace element research, 2004 - Springer
Patients on total parenteral nutrition without Cr supplementation develop symptoms similar
to those of diabetes. Zn has been implicated in diabetes because of its antioxidant …

[HTML][HTML] Chromium–insulin reduces insulin clearance and enhances insulin signaling by suppressing hepatic insulin-degrading enzyme and proteasome protein …

ZQ Wang, Y Yu, XH Zhang… - Frontiers in endocrinology, 2014 - frontiersin.org
JDS–chromium–insulin (CRI)-003 is a novel form of insulin that has been directly
conjugated with chromium (Cr) instead of zinc. Our hypothesis was that CRI enhances …

Chromium improves glucose uptake and metabolism through upregulating the mRNA levels of IR, GLUT4, GS, and UCP3 in skeletal muscle cells

W Qiao, Z Peng, Z Wang, J Wei, A Zhou - Biological trace element …, 2009 - Springer
The aim of this study was to evaluate the impact of three different chromium forms as
chromic chloride (CrCl), chromium picolinate (CrPic), and a newly synthesized complex of …

[HTML][HTML] Exercise affects blood glucose levels and tissue chromium distribution in high-fat diet-fed C57BL6 mice

GR Chang, PH Hou, WK Chen, CT Lin, HP Tsai… - Molecules, 2020 - mdpi.com
Obesity is commonly associated with hyperglycemia and type 2 diabetes and negatively
affects chromium accumulation in tissues. Exercise prevents and controls obesity and type 2 …