Objective To review the pharmacology, pharmacokinetics, efficacy, safety, and place in
therapy of rimegepant for treatment of migraine. Data Sources A comprehensive PubMed …

Background The triptans, selective serotonin 5-HT 1B/1D agonists, are very effective acute
migraine drugs with a well-developed scientific rationale. Seven different triptans will soon …

Migraine headaches are widespread, debilitating and considered a main cause of disability
worldwide. Symptoms of migraines include unilateral, pulsating pain that can last for hours …

Background Triptans are migraine-specific acute treatments. A well-accepted definition of
triptan failure is needed in clinical practice and for research. The primary aim of the present …

The introduction of the triptans brought advances in achieving complete and sustained pain
resolution in migraine patients, compared with non-migraine-specific treatments. However …

(Headache 2011; 51: 73‐84) Objective.—To evaluate the long‐term tolerability of
telcagepant for acute treatment of intermittent migraine attacks. Background.—Telcagepant …

Objective: A systematic review of the literature was undertaken, to consolidate evidence
concerning the efficacy and safety of triptans currently available in Canada (sumatriptan …

OBJECTIVE: To determine the cost-effectiveness of the 5-HT1B/1D agonists, or triptans, in
the acute treatment of migraine. METHODS: To determine the cost-effectiveness of the …

Objective To examine the effect of sex on clinical response to triptans in migraine and to
determine whether these differences are related to pharmacokinetics of triptans in men and …

Objectives: To develop and compare benefit-risk profiles for rimegepant, ubrogepant, and
lasmiditan based on a network meta-analysis (NMA) of published clinical trials. Methods: A …