New molecular cytogenetic biomarkers may significantly contribute to biodosimetry, whose
application is still globally diverse and not fully standardized. In 2011, a new term …

Purpose: To compare the occurrence of cytogenetically abnormal rogue cells, characterized
by a high frequency of chromosometype aberrations, in people exposed to ionizing radiation …

Cells with specific multiple chromosome aberrations, defined as rogue cells (RC) have been
described in different populations, predominantly those exposed to radiation. The frequency …

Chromothripsis has been defined as complex patterns of alternating genes copy number
changes (normal, gain or loss) along the length of a chromosome or chromosome segment …

In recent years, the paradigm that genomic abnormalities in cancer cells arise through
progressive accumulation of mutational events has been challenged by the discovery of …

Background Chromosome rearrangements play an important role in cancer
pathophysiology. Recently, chromothripsis has been proposed among the mechanisms …

Cultured lymphocytes exhibiting extreme cytogenetic damage (rogue cells) were observed
in preparations from 8 of 24 individuals sampled in Krasilovka, a Ukrainian village receiving …

The understanding of the connection between malignant cell transformation and genetic
instability has existed for a long time. Such markers of genetic instability as micronuclei (MN) …

One of the well-known hallmarks of cancer is genomic instability. Although gradualism is a
well-established process of cancer evolution, recent studies have shown that chromothripsis …

A cytogenetic analysis was performed on peripheral blood lymphocytes from 183 Chernobyl
clean-up workers and 27 control individuals. Increased frequencies of chromosome …