Stem cells undergo differentiation in complex and dynamic environments wherein instructive
signals fluctuate on various timescales. Thus, cells must be equipped to properly respond to …

Human neural progenitor cells (hNPCs) form a new prospect for replacement therapies in
the context of neurodegenerative diseases. The Wnt/-catenin signaling pathway is known to …

WNT/β-catenin signaling is crucial to all stages of life. It controls early morphogenetic events
in embryos, maintains stem cell niches in adults, and is dysregulated in many types of …

The fate of neural progenitor cells (NPCs) is determined by a complex interplay of intrinsic
programs and extrinsic signals, very few of which are known. β-Catenin transduces …

Wnt/β-catenin signalling has a variety of roles in regulating stem cell fates. Its specific role in
mouse epiblast stem cell self-renewal, however, remains poorly understood. Here we show …

Neurons and glia in the central nervous system originate from neural stem and progenitor
cells that reside in the ventricular zones. Here we examine the role of β‐catenin in neural …

Wnt signaling has recently emerged as a key factor in controlling stem cell expansion. In
contrast, we show here that Wnt/β-catenin signal activation in emigrating neural crest stem …

Cells have developed numerous adaptation mechanisms to external cues by controlling
signaling-pathway activity, both qualitatively and quantitatively. The Wnt/β-catenin pathway …

Neural crest cells are embryonic progenitors that generate numerous cell types in
vertebrates. With single-cell analysis, we show that mouse trunk neural crest cells become …

β-Catenin is an essential component of the canonical Wnt signaling system that controls
decisive steps in development. We employed here two conditional β-catenin mutant alleles …