The blood-brain barrier (BBB) is a barrier of the central nervous system (CNS), which can
restrict the free exchange of substances, such as toxins and drugs, between cerebral …

Maintenance of the tightly regulated homeostatic environment of the brain is facilitated by
the blood–brain barrier (BBB). P-glycoprotein (P-gp), an ATP-binding cassette transporter, is …

P-glycoprotein (P-gp) is known to transport a diverse array of xenobiotics, including
therapeutic drugs. A member of the ATP-binding cassette (ABC) transporter family, P-gp is a …

Objectives To investigate modulation of P-glycoprotein (P-gp) in rat brain microvessel
endothelial cells (rBMECs) under oxygen glucose deprivation (OGD). Methods The …

Drug delivery to the central nervous system (CNS) is greatly limited by the blood-brain
barrier (BBB). Physical and biochemical properties of the BBB have rendered treatment of …

The drug efflux transporter permeability glycoprotein (P-gp) plays an important role in oral
drug absorption and distribution. Under microgravity (MG), the changes in P-gp efflux …

Protection of the brain is strengthened by active transport and ABC transporters. P-
glycoprotein (P-gp) at the blood-brain barrier (BBB) functions as an active efflux pump by …

Recent advances in studies on the blood-brain barrier (BBB) transport of xenobiotics, as well
as nutrients and neuroactive agents, have led to a change in the classical concept that the …

The aim of the study was to investigate whether repetitive/temporal hypoxia up-regulated P-
glycoprotein (P-gp) in cultured rat brain microvasular endothelial cells (rBMECs). Cultured …

P-glycoprotein is an ATP (adenosine triphosphate)-driven drug efflux transporter that is
highly expressed at the blood–brain barrier (BBB) and is a major obstacle to the …