The objective of this study was to establish the optimal blood concentrations of the potent P-
glycoprotein (P-gp) inhibitor GF120918 (Elacridar) required to achieve maximal knockout of …

Neuronal damage after stroke-associated brain hypoxia is a leading cause of long-term
disability and death. The refractoriness to therapeutic strategies for neuroprotection after 3 h …

Endothelial dysfunction and blood-brain barrier (BBB) leakage have been suggested as a
fundamental role in the development of cerebral small vessel disease (SVD) pathology …

The aim was to investigate the effect of diabetes mellitus (DM) on P-glycoprotein (P-GP)
function and expression in rat blood–brain barrier (BBB). P-GP function in BBB was …

Background Brain capillary endothelial cells (BCECs) experience hypoxic conditions during
early brain development. The newly formed capillaries are tight and functional before …

The blood-brain barrier (BBB) is a metabolic and physiological barrier important for
maintaining brain homeostasis. The aim of this study was to determine the role of PKC …

Brain capillary endothelial cells form the blood–brain barrier (BBB), a highly selective
permeability membrane between the blood and the brain. Besides tight junctions that …

We used positron emission tomography (PET) to evaluate the contribution of P‐glycoprotein
(P‐gp), present at the human blood–brain barrier (BBB), to regional drug distribution in the …

Purpose The expression of P-glycoprotein (Pgp) is increased in brain capillary endothelial
cells (BCECs) of patients with pharmacoresistant epilepsy. This may restrict the penetration …

P-glycoprotein (P-gp) expression at the blood–brain barrier prevents unwanted blood-borne
toxins and signalling molecules from entering the brain. Primary and immortalised human …