With heart failure leading the cause of death in the USA (Hunt), biomedical research is
fundamental to advance medical treatments for cardiovascular diseases. Animal models that …

Acute or chronic myocardial infarction (MI) are cardiovascular events resulting in high
morbidity and mortality. Establishing the pathological mechanisms at work during MI and …

Heart failure is a syndrome in which the heart fails to pump blood at a rate commensurate
with cellular oxygen requirements at rest or during stress. It is characterized by fluid …

Despite significant improvements in reperfusion strategies, acute coronary syndromes all too
often culminate in a myocardial infarction (MI). The consequent MI can, in turn, lead to …

After myocardial infarction, remodeling of the left ventricle involves a wound-healing
orchestra involving a variety of cell types. In order for wound healing to be optimal …

The murine in vivo model of acute myocardial infarction is increasingly used to study signal
transduction pathways. However, methodological details of this model are rarely published …

In patients with myocardial infarction (MI), cardiac rupture is an uncommon but catastrophic
complication. In the mouse model of nonreperfused MI, reported rupture rates are highly …

Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the
efficacy of cardioprotective interventions prior to clinical translation. Nonetheless, current …

Mouse models of myocardial infarction are essential tools for the study of cardiac injury,
repair, and remodeling. Our current investigation establishes a systematic approach for …

Mouse surgical models are important tools for evaluating mechanisms of human cardiac
disease. The clinically relevant comorbidities of hypertension and ischaemia have not been …