Elevated plasma levels of low-density lipoprotein and generation of oxidized low-density
lipoprotein have been directly associated with the pathogenesis of atherosclerosis, and lipid …

During inflammatory processes biologically active lipid oxidation products accumulate that
modulate the inflammatory process and may determine the fate and outcome of the body's …

Atherosclerosis is a chronic inflammatory disease and a leading cause of human mortality.
The lesional microenvironment contains a complex accumulation of variably oxidized lipids …

Earlier studies investigating the pathogenesis of chronic vascular inflammation associated
with atherosclerosis described pro-inflammatory and vascular barrier disruptive effects of …

Oxidized phospholipids, such as the products of the oxidation of 1-palmitoyl-2-arachidonoyl-
sn-glycero-3-phosphocholine by nonenzymatic radical attack, are known to be formed in a …

Objective—Oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycero-phosphorylcholine (Ox-PAPC)
and its component phospholipid, 1-palmitoyl-2-(5, 6 epoxyisoprostanoyl)-sn-glycero-3 …

Objective—Lipoprotein-derived phospholipid oxidation products have been implicated as
candidate triggers of the inflammatory process in atherosclerosis. However, in vivo evidence …

Biologically active oxidized phospholipids can initiate and modulate many of the cellular
events attributed to inflammation leading to atherosclerosis. Produced by enzymatic or non …

Oxidized phospholipids accumulate in atherosclerotic lesions, on lipoproteins, in other
states of chronic inflammation, on apoptotic cells, necrotic cells and cells exposed to …

Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly
recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL …