Cyclosporine (CsA) and tacrolimus (TAC) are immunosuppressant drugs characterized by a
narrow therapeutic range and high pharmacokinetic variability. The effect of polymorphisms …

Abstract Purpose Tacrolimus (Tac) and cyclosporine (CsA) are mainly metabolized by
CYP3A4 and CYP3A5. Several studies have demonstrated an association between the …

Cyclosporine and tacrolimus are immunosuppressive drugs largely used in renal
transplantation. They are characterized by a wide inter-individual variability in their …

Summary Background: Calcineurin inhibitor (cyclosporine, CsA) and mTOR inhibitors
(sirolimus, SRL)–immunosuppressants used to prevent allograft rejection after renal …

Cyclosporine, everolimus, and tacrolimus are the cornerstone of immunosuppressive
therapy in renal transplantation. These drugs are characterized by narrow therapeutic …

Background: Kidney transplant recipients on long-term cyclosporine (CsA) therapy may
develop multiple adverse drug events, and immunosuppression conversion from CsA to …

Objective The immunosuppressive drug tacrolimus requires strict therapeutic monitoring due
to its narrow therapeutic index and great inter-individual variability. Cytochrome P450 3A4 …

Most immunosuppressive drugs have a narrow therapeutic index and large interpatient
variabilities in their pharmacokinetic and pharmacodynamic profiles. Identification of …

Aims: The calcineurin inhibitors cyclosporine and tacrolimus are the major
immunosuppressive agents, It becomes complicated to use them for their interindividual …

Tacrolimus is a commonly used immunosuppressant after kidney transplantation. It has a
narrow therapeutic range and demonstrates wide interindividual variability in …