[HTML][HTML] Evaluation of a Clinically Relevant Drug–Drug Interaction Between Rosuvastatin and Clopidogrel and the Risk of Hepatotoxicity
C Ning, S Su, J Li, D Kong, H Cai, Z Qin… - Frontiers in …, 2021 - frontiersin.org
Purpose: The combination therapy of rosuvastatin (RSV) and the platelet inhibitor
clopidogrel (CP) is widely accepted in the management of cardiovascular diseases. The …
clopidogrel (CP) is widely accepted in the management of cardiovascular diseases. The …
Clarification of the mechanism of clopidogrel-mediated drug–drug interaction in a clinical cassette small-dose study and its prediction based on in vitro information
SJ Kim, T Yoshikado, I Ieiri, K Maeda, M Kimura… - Drug Metabolism and …, 2016 - ASPET
Clopidogrel is reported to be associated with cerivastatin-induced rhabdomyolysis, and
clopidogrel and its metabolites are capable of inhibiting CYP2C8 and OATP 1B1 in vitro …
clopidogrel and its metabolites are capable of inhibiting CYP2C8 and OATP 1B1 in vitro …
[HTML][HTML] Physiologically based pharmacokinetic modeling of rosuvastatin to predict transporter-mediated drug-drug interactions
N Hanke, JD Gómez-Mantilla, N Ishiguro… - Pharmaceutical …, 2021 - Springer
Purpose To build a physiologically based pharmacokinetic (PBPK) model of the clinical
OATP1B1/OATP1B3/BCRP victim drug rosuvastatin for the investigation and prediction of its …
OATP1B1/OATP1B3/BCRP victim drug rosuvastatin for the investigation and prediction of its …
Effects of atazanavir/ritonavir or fosamprenavir/ritonavir on the pharmacokinetics of rosuvastatin
Background: Rosuvastatin (RSV) is a potent statin with a lower potential for drug
interactions. However, recent data have revealed unexpected increases in RSV …
interactions. However, recent data have revealed unexpected increases in RSV …
Pharmacokinetic interactions between clopidogrel and rosuvastatin: effects on vascular protection in subjects with coronary heart disease
LF Pinheiro, CN França… - International …, 2012 - internationaljournalofcardiology.com
Significant decrease in outcomes with statins administration in the first 24 h of an acute
myocardial infarction [1–4] and reduction of myocardial injury markers after high-dose statin …
myocardial infarction [1–4] and reduction of myocardial injury markers after high-dose statin …
Positron Emission Tomography Imaging of [11C]Rosuvastatin Hepatic Concentrations and Hepatobiliary Transport in Humans in the Absence and Presence of …
S Billington, S Shoner, S Lee… - Clinical …, 2019 - Wiley Online Library
Using positron emission tomography imaging, we determined the hepatic concentrations
and hepatobiliary transport of [11C] rosuvastatin (RSV; iv injection) in the absence (n= 6) …
and hepatobiliary transport of [11C] rosuvastatin (RSV; iv injection) in the absence (n= 6) …
The mechanism and risk factors of clopidogrel-induced liver injury
Context and objective: Clopidogrel (CLP) is a prodrug which is widely used as a platelet
aggregation inhibitor. Hepatotoxicity is rare but a potentially serious adverse reaction that is …
aggregation inhibitor. Hepatotoxicity is rare but a potentially serious adverse reaction that is …
Clopidogrel has no clinically meaningful effect on the pharmacokinetics of the organic anion transporting polypeptide 1B1 and cytochrome P450 3A4 substrate …
MK Itkonen, A Tornio, M Neuvonen… - Drug Metabolism and …, 2015 - ASPET
Simvastatin and clopidogrel are commonly used together in the treatment of cardiovascular
diseases. Organic anion transporting polypeptide (OATP) 1B1 activity markedly affects the …
diseases. Organic anion transporting polypeptide (OATP) 1B1 activity markedly affects the …
Clopidogrel has no clinically meaningful effect on the pharmacokinetics of the OATP1B1 and CYP3A4 substrate simvastatin
MK Itkonen, A Tornio, M Neuvonen… - Drug Metabolism and …, 2015 - ASPET
Simvastatin and clopidogrel are commonly used together in the treatment of cardiovascular
diseases. Organic anion transporting polypeptide (OATP) 1B1 activity markedly affects the …
diseases. Organic anion transporting polypeptide (OATP) 1B1 activity markedly affects the …
Carboxylesterase 1-Mediated Drug–Drug Interactions between Clopidogrel and Simvastatin
Patients with coronary artery disease often receive concurrent treatment with clopidogrel
and a hydroxymethylglutaryl (HMG)-CoA reductase inhibitor medication. Accordingly …
and a hydroxymethylglutaryl (HMG)-CoA reductase inhibitor medication. Accordingly …