Background: Acute kidney injury (AKI) is one of the major risk factors for progression to
chronic kidney disease (CKD) and renal fibrosis. However, effective therapies remain poorly …

Renal ischemia-reperfusion injury (IRI) is a complex syndrome, which causes chronic kidney
disease (CKD) after recovery from IRI-mediated acute kidney injury (AKI). There is no single …

Objective To investigate the effects and molecular mechanism of melatonin (MT) on NF-κB
and TGF-β/Smad3 signaling pathways in db/db diabetic mice. Methods db/db diabetic mice …

Diabetes-mediated hyperglycemia is a major risk factor for renal fibrosis, resulting in the
development of chronic kidney diseases. To address this issue, the effect of melatonin …

Fibroblast‐myofibroblast transdifferentiation (FMT) is widely recognized as the major
pathological feature of renal fibrosis. Although melatonin has exerted antifibrogenic activity …

Diabetic nephropathy (DN) is a severe renal disorder characterized by podocyte damage
and accumulation of extracellular matrix leading to further glomerulosclerosis, possibly via …

Melatonin (MT), a hormone secreted from the pineal gland, has beneficial effects on the
development of diabetic nephropathy (DN). In our study, we aimed to determine the effects …

Accumulating evidence suggests that the pineal hormone melatonin displays protective
effects against renal fibrosis, but the mechanisms remain poorly understood. Here, we …

Mitochondrial homeostasis is a highly regulated process that serves a critical role in the
maintenance of renal structure and function. The growing interest in the field of …

Melatonin (N-acetyl-5-methoxytryptamine; MLT) has been shown to have a renal-protective
effect against kidney injury. However, the mechanisms underlying the protective role of MLT …