Results There were modest associations of CASR SNPs with increased baseline serum
parathyroid hormone and bone alkaline phosphatase primarily with the minor allele in the …

The objective of this study was to determine the impact of calcium sensing receptor (CASR)
A990G genetic polymorphism on parathyroid hormone (PTH) lowering response to …

Aims: Calcimimetics are effective in reducing parathyroid hormone (PTH) levels in patients
with secondary hyperparathyroidism, but variability in dose response has been noted. We …

Abstract Nephrolithiasis, secondary hyperparathyroidism (sHPT), and cardiovascular
complications are associated with disturbances in Ca handling and contribute to …

Abstract Background/Aims: The calcium-sensing receptor gene (CASR) rs1801725 variant is
responsible for a non-conservative amino-acid change (A986S) in the calcium-sensing …

Cinacalcet, a novel calcimimetic compound, is effective in reducing parathyroid hormone
(PTH) levels in approximately 70% of patients with secondary hyperparathyroidism …

Back ground: CaSR al lows para thyroid and kid ney tu bu lar cells to reg u late PTH se cre
tion and tu bu lar cal cium re ab sorption. In the pres ent re port, we ex am ined the re la tion …

Background: Cinacalcet hydrochloride (cinacalcet), a calcimimetic, has been shown to
upregulate calcium-sensing receptor (CaSR) expression in parathyroid glands of rats with …

The present study was performed to investigate the association of calcium-sensing receptor
(CaSR) genotypes with parathyroid hormone (PTH) secretion in hemodialysis patients …

Background Secondary hyperparathyroidism (SHPT) is one of the major risk factors of
morbidity and mortality in end-stage renal disease. Cinacalcet effectively controls SHPT …