Faithful mitotic chromosome segregation is required for the maintenance of genomic
stability. We discovered the phosphorylation of histone H2B at serine 6 (H2B S6ph) as a …

The cyclin-dependent kinase CDK11 p58 is specifically expressed at G2/M phase. CDK11
p58 depletion leads to different cell cycle defects such as mitotic arrest, failure in centriole …

Histone H2A phosphorylation plays a role both in chromatin condensation during mitosis
and in transcriptional activation during the G1/S transition. Bub1 and NHK1/VRK1 have …

Failure in cytokinesis, the final step in cell division, by generating tetra-and polyploidization
promotes chromosomal instability, a hallmark of cancer. Here we show that HIPK2, a kinase …

Post‐translational modifications of histones play important roles in regulating chromatin
dynamics and epigenetic inheritance during mitosis. The epigenetic significance and …

We have generated and characterized a novel site-specific antibody highly specific for the
phosphorylated form of the amino-terminus of histone H3 (Ser10). In this study, we used this …

Interphasic chromatin condenses into the chromosomes in order to facilitate the correct
segregation of genetic information. It has been previously reported that the phosphorylation …

Posttranslational histone modifications regulate both gene expression and genome integrity.
Despite the dynamic nature of these modifications, appropriate real-time monitoring systems …

The coordination of mitotic spindle formation and chromatin condensation is an essential
prerequisite for successful mitosis. Both events are thought to be initiated by cyclin B/Cdk1 …

Defects in resolving kinetochore-microtubule attachment mistakes during mitosis is linked to
chromosome instability associated with carcinogenesis as well as resistance to cancer …