Background: Collectively, research on the role of B-cells in the pathogenesis of multiple
sclerosis (MS) illustrates how translational medicine has given rise to promising therapeutic …

There is ongoing debate on how B cells contribute to the pathogenesis of multiple sclerosis
(MS). The success of B‐cell targeting therapies in MS highlighted the role of B cells …

The success of clinical trials of selective B‐cell depletion in patients with relapsing multiple
sclerosis (MS) and primary progressive MS has led to a conceptual shift in the …

Increasing evidence has suggested that both antibody-dependent and antibody-
independent functions of B cells are involved in multiple sclerosis (MS). The contrasting …

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central
nervous system (CNS) that often progresses to severe disability. Previous studies have …

Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

B lymphocytes have essential roles in the autoimmune pathogenesis of multiple sclerosis
(MS). They regulate the autoimmune response and participate in the development of the …

Autoimmune B cells play a major role in mediating tissue damage in multiple sclerosis (MS).
In MS, B cells are believed to cross the blood-brain barrier and undergo stimulation, antigen …

Over the past two decades B cells have increasingly moved into the spotlight in multiple
sclerosis (MS) research. This interest was fuelled by growing understanding and acceptance …

For decades, B cells were ignored in multiple sclerosis (MS) pathogenesis, and the disease
was always regarded as a T cell‐mediated disorder. Recent evidence shows that there is an …