Gut commensal derived-valeric acid protects against radiation injuries

Y Li, J Dong, H Xiao, S Zhang, B Wang, M Cui… - Gut microbes, 2020 - Taylor & Francis
Background Hematopoietic and intestinal systems side effects are frequently found in
patients who suffered from accidental or medical radiation exposure. In this case, we …

[HTML][HTML] Gut microbiota-derived indole 3-propionic acid protects against radiation toxicity via retaining acyl-CoA-binding protein

H Xiao, M Cui, Y Li, J Dong, S Zhang, C Zhu, M Jiang… - Microbiome, 2020 - Springer
Background We have proved fecal microbiota transplantation (FMT) is an efficacious remedy
to mitigate acute radiation syndrome (ARS); however, the mechanisms remain incompletely …

[HTML][HTML] effect of gut microbiota and its metabolite SCFAs on radiation-induced intestinal injury

Y Li, Y Zhang, K Wei, J He, N Ding, J Hua… - Frontiers in cellular …, 2021 - frontiersin.org
Gut microbiota is regarded as the second human genome and forgotten organ, which is
symbiotic with the human host and cannot live and exist alone. The gut microbiota performs …

[HTML][HTML] The vanillin derivative VND3207 protects intestine against radiation injury by modulating p53/NOXA signaling pathway and restoring the balance of gut …

M Li, MM Gu, Y Lang, J Shi, BPC Chen, H Guan… - Free Radical Biology …, 2019 - Elsevier
The intestine is a highly radiosensitive tissue that is susceptible to structural and functional
damage due to systemic as well as localized radiation exposure. Unfortunately, no effective …

Faecal microbiota transplantation protects against radiation‐induced toxicity

M Cui, H Xiao, Y Li, L Zhou, S Zhao, D Luo… - EMBO molecular …, 2017 - embopress.org
Severe radiation exposure may cause acute radiation syndrome, a possibly fatal condition
requiring effective therapy. Gut microbiota can be manipulated to fight against many …

Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites

H Guo, WC Chou, Y Lai, K Liang, JW Tam, WJ Brickey… - Science, 2020 - science.org
INTRODUCTION The toxicity of high-dose ionizing radiation is associated with the induction
of both chronic and acute radiation syndromes that occur after partial or total body radiation …

[HTML][HTML] Dysbiosis of gut microbiota is associated with the progression of radiation-induced intestinal injury and is alleviated by oral compound probiotics in mouse …

TS Zhao, LW Xie, S Cai, JY Xu, H Zhou… - Frontiers in cellular …, 2021 - frontiersin.org
The acute radiation-induced intestinal injury (RIII) has raised much concerns and is
influenced by non-cytocidal radiation effects including the perturbations in gut microbiota …

Sexual dimorphism of gut microbiota dictates therapeutics efficacy of radiation injuries

M Cui, H Xiao, Y Li, S Zhang, J Dong… - Advanced …, 2019 - Wiley Online Library
Accidental or iatrogenic ionizing radiation exposure precipitates acute and chronic radiation
injuries. The traditional paradigm of mitigating radiotherapy‐associated adverse side effects …

An integrated multi-omic approach to assess radiation injury on the host-microbiome axis

M Goudarzi, TD Mak, JP Jacobs… - Radiation …, 2016 - meridian.allenpress.com
Medical responders to radiological and nuclear disasters currently lack sufficient high-
throughput and minimally invasive biodosimetry tools to assess exposure and injury in the …

[HTML][HTML] Alterations of the gut microbiome composition and lipid metabolic profile in radiation enteritis

Y Li, H Yan, Y Zhang, Q Li, L Yu, Q Li, C Liu… - Frontiers in cellular …, 2020 - frontiersin.org
Radiation enteritis (RE) is a common complication in cancer patients receiving radiotherapy.
Although studies have shown the changes of this disease at clinical, pathological and other …