[HTML][HTML] Vasoprotective endothelial effects of chronic cannabidiol treatment and its influence on the endocannabinoid system in rats with primary and secondary …
M Baranowska-Kuczko, H Kozłowska, M Kloza… - Pharmaceuticals, 2021 - mdpi.com
Our study aimed to examine the endothelium (vascular)-protecting effects of chronic
cannabidiol (CBD) administration (10 mg/kg once daily for 2 weeks) in aortas and small …
cannabidiol (CBD) administration (10 mg/kg once daily for 2 weeks) in aortas and small …
[HTML][HTML] In Vivo Cannabidiol Treatment Improves Endothelium-Dependent Vasorelaxation in Mesenteric Arteries of Zucker Diabetic Fatty Rats
AJ Wheal, K Jadoon, MD Randall… - Frontiers in …, 2017 - frontiersin.org
Background and purpose: We have shown that in vitro treatment with cannabidiol (CBD, 2 h)
enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a …
enhances endothelial function in arteries from Zucker diabetic fatty (ZDF) rats, partly due to a …
[HTML][HTML] Vasodilatory effects of cannabidiol in human pulmonary and rat small mesenteric arteries: Modification by hypertension and the potential pharmacological …
M Baranowska-Kuczko, H Kozlowska… - Journal of …, 2020 - journals.lww.com
Objective: Cannabidiol (CBD) has been suggested as a potential antihypertensive drug. The
aim of our study was to investigate its vasodilatory effect in isolated human pulmonary …
aim of our study was to investigate its vasodilatory effect in isolated human pulmonary …
[HTML][HTML] Chronic cannabidiol administration fails to diminish blood pressure in rats with primary and secondary hypertension despite its effects on cardiac and plasma …
P Remiszewski, I Jarocka-Karpowicz… - International Journal of …, 2020 - mdpi.com
We investigated the influence of cannabidiol (CBD) on blood pressure (BP) and heart rate
(HR) in spontaneously (SHR) and deoxycorticosterone (DOCA-salt) hypertensive rats …
(HR) in spontaneously (SHR) and deoxycorticosterone (DOCA-salt) hypertensive rats …
Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes
CP Stanley, AJ Wheal, MD Randall… - European journal of …, 2013 - Elsevier
Circulating levels of anandamide are increased in diabetes, and cannabidiol ameliorates a
number of pathologies associated with diabetes. The aim of the present study was to …
number of pathologies associated with diabetes. The aim of the present study was to …
Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation
Aims The protective effects of cannabidiol (CBD) have been widely shown in preclinical
models and have translated into medicines for the treatment of multiple sclerosis and …
models and have translated into medicines for the treatment of multiple sclerosis and …
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
Background—Endocannabinoids are novel lipid mediators with hypotensive and
cardiodepressor activity. Here, we examined the possible role of the endocannabinergic …
cardiodepressor activity. Here, we examined the possible role of the endocannabinergic …
Cannabidiol improves vasorelaxation in Zucker diabetic fatty rats through cyclooxygenase activation
AJ Wheal, M Cipriano, CJ Fowler, MD Randall… - … of Pharmacology and …, 2014 - ASPET
Cannabidiol (CBD) decreases insulitis, inflammation, neuropathic pain, and myocardial
dysfunction in preclinical models of diabetes. We recently showed that CBD also improves …
dysfunction in preclinical models of diabetes. We recently showed that CBD also improves …
Chronic treatment with the cannabinoid 1 antagonist rimonabant altered vasoactive cyclo-oxygenase-derived products on arteries from obese Zucker rats
C Mingorance, MA de Sotomayor… - Journal of …, 2010 - journals.lww.com
To investigate the effect of chronic cannabinoid 1 antagonism on vascular prostanoid
production, obese Zucker rats were treated with rimonabant (10 mg/kg per day) during 20 …
production, obese Zucker rats were treated with rimonabant (10 mg/kg per day) during 20 …
ACPA and JWH-133 modulate the vascular tone of superior mesenteric arteries through cannabinoid receptors, BKCa channels, and nitric oxide dependent …
E López-Dyck, F Andrade-Urzúa, A Elizalde… - Pharmacological …, 2017 - Springer
Background Some cannabinoids, a family of compounds derived from Cannabis sativa
(marijuana), have previously shown vasodilator effects in several studies, a feature that …
(marijuana), have previously shown vasodilator effects in several studies, a feature that …