Emerging precision neoadjuvant systemic therapy for patients with resectable non-small cell lung cancer: current status and perspectives

LA Godoy, J Chen, W Ma, J Lally, KA Toomey… - Biomarker …, 2023 - Springer
Over the past decade, targeted therapy for oncogene-driven NSCLC and immune
checkpoint inhibitors for non-oncogene-driven NSCLC, respectively, have greatly improved …

[HTML][HTML] Neoadjuvant therapy in non-small cell lung cancer

C Grant, G Hagopian, M Nagasaka - Critical Reviews in Oncology …, 2023 - Elsevier
Non-small cell lung cancer (NSCLC) stages I-III were previously predominantly treated with
surgery and chemotherapy. With the advent of Checkmate-816, neoadjuvant nivolumab and …

[HTML][HTML] Role and impact of immune checkpoint inhibitors in neoadjuvant treatment for NSCLC

A Friedlaender, J Naidoo, GL Banna, G Metro… - Cancer treatment …, 2022 - Elsevier
In the last decade, immune-checkpoint inhibitors (ICIs) have become the backbone of
therapy in advanced, non-oncogene driven, non-small cell lung cancer (NSCLC). More …

Neoadjuvant nivolumab plus chemotherapy in resectable lung cancer

PM Forde, J Spicer, S Lu, M Provencio… - … England Journal of …, 2022 - Mass Medical Soc
Background Neoadjuvant or adjuvant chemotherapy confers a modest benefit over surgery
alone for resectable non–small-cell lung cancer (NSCLC). In early-phase trials, nivolumab …

[HTML][HTML] Emerging biomarkers for neoadjuvant immune checkpoint inhibitors in operable non-small cell lung cancer

M Pradhan, M Chocry, DL Gibbons… - Translational Lung …, 2021 - ncbi.nlm.nih.gov
The advent of immune checkpoint inhibitors (ICIs) has dramatically changed the treatment of
patients with locally advanced unresectable and metastatic non-small cell lung cancer …

Overall survival and biomarker analysis of neoadjuvant nivolumab plus chemotherapy in operable stage IIIA non–small-cell lung cancer (NADIM phase II trial)

M Provencio, R Serna-Blasco, E Nadal… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE Neoadjuvant chemotherapy plus nivolumab has been shown to be effective in
resectable non–small-cell lung cancer (NSCLC) in the NADIM trial (ClinicalTrials. gov …

Neoadjuvant chemo/immunotherapy for the treatment of stages IIIA resectable non-small cell lung cancer (NSCLC): A phase II multicenter exploratory study—NADIM …

M Provencio-Pulla, E Nadal-Alforja, M Cobo, A Insa… - 2018 - ascopubs.org
8521 Background: The combination of chemotherapy and immunotherapy (CT-IO) has a
high response rate and longer survival in unselected patients (pts) with metastatic non-small …

Two vs three cycles of neoadjuvant sintilimab plus chemotherapy for resectable non-small-cell lung cancer: neoSCORE trial

M Shao, J Yao, Y Wang, L Zhao, B Li, L Li… - … and Targeted Therapy, 2023 - nature.com
Lung cancer is the predominant cause of cancer-related deaths globally, with non-small cell
lung cancer (NSCLC) accounting for 85% of all cases. 1 The five-year overall survival (OS) …

Neoadjuvant and adjuvant systemic therapy for early-stage non-small-cell lung cancer

J Isaacs, TE Stinchcombe - Drugs, 2022 - Springer
Approximately a third of patients with non-small-cell lung cancer (NSCLC) present with
surgically resectable disease. Patients who undergo surgical resection are at a high risk of …

Neoadjuvant chemotherapy and nivolumab in resectable non-small-cell lung cancer (NADIM): an open-label, multicentre, single-arm, phase 2 trial

M Provencio, E Nadal, A Insa… - The Lancet …, 2020 - thelancet.com
Background Non-small-cell lung cancer (NSCLC) is terminal in most patients with locally
advanced stage disease. We aimed to assess the antitumour activity and safety of …