Rationale: Extraembryonic tissues, including the yolk sac and placenta, and the heart within
the embryo, work to provide crucial nutrients to the embryo. The association of congenital …

The heart develops from 2 sources of mesoderm progenitors, the first and second heart field
(FHF and SHF). Using a single-cell transcriptomic assay combined with genetic lineage …

Organogenesis requires the orchestrated development of multiple cell lineages that
converge, interact, and specialize to generate coherent functional structures, exemplified by …

The mammalian heart is a highly specialized organ, comprised of many different cell types
arising from distinct embryonic progenitor populations during cardiogenesis. Three …

Mammalian heart development requires precise allocation of cardiac progenitors. The
existence of a multipotent progenitor for all anatomic and cellular components of the heart …

Publisher Summary To understand the molecular mechanisms that govern sequentially
programmed development and integration of these subcardiac components during heart …

Cardiac development arises from two sources of mesoderm progenitors, the first heart field
(FHF) and the second (SHF). Mesp1 has been proposed to mark the most primitive …

Using four-dimensional whole-embryo light sheet imaging with improved and accessible
computational tools, we longitudinally reconstruct early murine cardiac development at …

In the mouse, the earliest heart precursors can be traced to approximately 50 founder cells
located on both sides of the midline in the epiblast of early gastrula stage embryos (E6 …

The embryonic heart is composed of two cell layers: the myocardium, which contributes to
cardiac muscle tissue, and the endocardium, which covers the inner lumen of the heart …