GPER functions as a tumor suppressor in MCF-7 and SK-BR-3 breast cancer cells
C Weißenborn, T Ignatov, A Poehlmann… - Journal of cancer …, 2014 - Springer
Purpose The orphan, membrane-bound estrogen receptor (GPER) is expressed at high
levels in a large fraction of breast cancer patients, and its expression is favorable for …
levels in a large fraction of breast cancer patients, and its expression is favorable for …
GPER functions as a tumor suppressor in triple-negative breast cancer cells
C Weißenborn, T Ignatov, HJ Ochel, SD Costa… - Journal of cancer …, 2014 - Springer
Background The orphan, membrane-bound estrogen receptor (GPER) is expressed at high
levels in a large fraction of breast cancer patients and its expression is favorable for patients' …
levels in a large fraction of breast cancer patients and its expression is favorable for patients' …
A novel estrogen receptor GPER mediates proliferation induced by 17β‐estradiol and selective GPER agonist G‐1 in estrogen receptor α (ERα)‐negative ovarian …
H Liu, Y Yan, H Wen, X Jiang, X Cao… - Cell Biology …, 2014 - Wiley Online Library
G protein‐coupled estrogen receptor (GPER) is recently identified as a membrane‐
associated estrogen receptor that mediates non‐genomic effects of estrogen. Our previous …
associated estrogen receptor that mediates non‐genomic effects of estrogen. Our previous …
GPER Promoter Methylation Controls GPER Expression in Breast Cancer Patients
C Weissenborn, T Ignatov, N Nass, T Kalinski… - Cancer …, 2017 - Taylor & Francis
Recently, we found that G-protein-coupled estrogen receptor (GPER) protein expression
decreased during breast carcinogenesis, and that GPER promoter is methylated. Here we …
decreased during breast carcinogenesis, and that GPER promoter is methylated. Here we …
[HTML][HTML] GPER deletion triggers inhibitory effects in triple negative breast cancer (TNBC) cells through the JNK/c-Jun/p53/Noxa transduction pathway
F Cirillo, M Talia, MF Santolla, M Pellegrino… - Cell Death …, 2023 - nature.com
The G protein-coupled estrogen receptor (GPER) mediates estrogen action in different
pathophysiological conditions, including cancer. GPER expression and signaling have been …
pathophysiological conditions, including cancer. GPER expression and signaling have been …
[PDF][PDF] G-protein coupled estrogen receptor 1 expression in primary breast cancers and its correlation with clinicopathological variables
H Luo, P Luo, G Yang, M Liu, G Tu - Journal of breast …, 2011 - synapse.koreamed.org
Purpose: G-protein coupled estrogen receptor 1 (GPER) probably play important roles in the
progression of breast cancer including endocrine therapeutic resistance. We evaluated …
progression of breast cancer including endocrine therapeutic resistance. We evaluated …
[HTML][HTML] The G protein-coupled estrogen receptor (GPER) is expressed in two different subcellular localizations reflecting distinct tumor properties in breast cancer
EP Samartzis, A Noske, A Meisel, Z Varga, D Fink… - PloS one, 2014 - journals.plos.org
Introduction The G protein-coupled estrogen receptor (GPER) is a novel estrogen receptor
that mediates proliferative effects induced by estrogen but also by tamoxifen. The aim of our …
that mediates proliferative effects induced by estrogen but also by tamoxifen. The aim of our …
GPER-1 expression decreases during breast cancer tumorigenesis
T Ignatov, C Weißenborn, A Poehlmann… - Cancer …, 2013 - Taylor & Francis
GPER-1 protein expression was immunohistochemically examined in 164 primary breast
cancer specimens and their matched normal breast epithelium. GPER-1 down-regulation …
cancer specimens and their matched normal breast epithelium. GPER-1 down-regulation …
[HTML][HTML] GPER-1 acts as a tumor suppressor in ovarian cancer
T Ignatov, S Modl, M Thulig, C Weißenborn… - Journal of ovarian …, 2013 - Springer
Background It is known that the new membrane-bound estrogen receptor GPER-1 acts
suppressive in breast cancer cells and its expression decreases during disease …
suppressive in breast cancer cells and its expression decreases during disease …
[HTML][HTML] Mechanism of GPER promoting proliferation, migration and invasion of triple-negative breast cancer cells through CAF
K Yang, Y Yao - American Journal of Translational Research, 2019 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is an important histological subtype of breast cancer.
Abnormal GPER expression has been reported in human breast cancer. However, the …
Abnormal GPER expression has been reported in human breast cancer. However, the …