Our understanding of cystic fibrosis (CF) has grown exponentially since the discovery of the
cystic fibrosis transmembrane conductance regulator (CFTR) gene in 1989. With evolving …

Cystic fibrosis (CF) is the most common genetic disease among Caucasians and is caused
by mutations in the CF transmembrane conductance regulator (CFTR) gene. CF affects …

Understanding the causes of variation in clinical manifestations of disease should allow for
design of new or improved therapeutic strategies to treat the disease. If variation is caused …

Several genes have been demonstrated to affect disease severity in CF. Furthermore, it is
likely that gene–gene and gene–environment interactions can explain a substantial portion …

Since the discovery of the CFTR gene mutations which cause cystic fibrosis (CF) in 1989 the
average life expectancy of CF patients has almost doubled and now exceeds 37 years. The …

The genetic multisystem condition cystic fibrosis (CF) has seen a paradigm shift in
therapeutic approaches within the past decade. Since the first clinical descriptions in the …

Background Lung disease is the major source of morbidity and mortality in cystic fibrosis
(CF), with large variability in severity between patients. Although accurate prediction of lung …

Cystic fibrosis (CF) is the most common life-shortening genetic disease affecting~ 1 in 3,500
of the Caucasian population. CF is caused by mutations in the CF transmembrane …

Following discovery of the cystic fibrosis transmembrane conductance regulator (CFTR)
gene in 1989 and subsequent elucidation of the varied CFTR protein abnormalities that …

Cystic fibrosis (CF) is recognized as a single gene disorder. However, a considerable
diversity in its clinical phenotype has been documented since the description of the disease …