Bioproduction of natural products via microbial cell factories is a promising alternative to
traditional plant extraction. Recently, nonconventional microorganisms have emerged as …

Plant-derived natural active products have attracted increasing attention for use in flavors
and perfumes. These compounds also have applications in insect pest control because of …

The diterpenoid sclareol is an industrially important precursor for alternative sustainable
supply of ambergris. However, its current production from plant extraction is neither …

Abstract β‐elemene is one of the most commonly used antineoplastic drugs in cancer
treatment. As a plant‐derived natural chemical, biologically engineering microorganisms to …

Flavonoids are a large family of plant and fungal natural products, among which many have
been found to possess outstanding biological activities. Utilization of engineered microbes …

Terpenoids are a large family of natural products with diversified structures and functions
that are widely used in the food, pharmaceutical, cosmetic, and agricultural fields. However …

Saponins are a structurally diverse family of triterpenes that are widely found as main
constituents in many traditional plant-based medicines and often have bioactivities of …

Combinatorial genome integration of mevalonate pathway genes was performed with the
aim of optimizing the metabolic flux for improved production of terpenoids in budding yeast …

Bio-manufacturing via microbial cell factory requires large promoter library for fine-tuned
metabolic engineering. Ogataea polymorpha, one of the methylotrophic yeasts, possesses …

Abstract Background (+)-Nootkatone is a highly valued sesquiterpenoid compound,
exhibiting a typical grapefruit aroma and various desired biological activities for use as …