Cytotoxicity models of Huntington's disease and relevance of hormetic mechanisms: A critical assessment of experimental approaches and strategies
This paper assesses in vivo cytotoxicity models of Huntington's disease (HD). Nearly 150
agents were found to be moderately to highly effective in mitigating the pathological …
agents were found to be moderately to highly effective in mitigating the pathological …
Rodent Models of Huntington's Disease: An Overview
Huntington's disease (HD) is an autosomal-dominant inherited neurological disorder caused
by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a …
by a genetic mutation in the IT15 gene. This neurodegenerative disorder is caused by a …
Animal models of Huntington's disease and their applicability to novel drug discovery and development
Introduction Huntington's disease (HD) is a progressive neurodegenerative disorder caused
by an expansion in the CAG trinucleotide repeat in huntingtin (Htt) gene. The discovery of …
by an expansion in the CAG trinucleotide repeat in huntingtin (Htt) gene. The discovery of …
Modeling Huntington's disease: An insight on in-vitro and in-vivo models
Huntington's disease is a neurodegenerative illness that causes neuronal death most
extensively within the basal ganglia. There is a broad class of neurologic disorders …
extensively within the basal ganglia. There is a broad class of neurologic disorders …
[HTML][HTML] Mouse models of Huntington's disease and methodological considerations for therapeutic trials
RJ Ferrante - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2009 - Elsevier
Huntington's disease (HD) is an autosomal dominant, progressive, and fatal
neurodegenerative disorder caused by an expanded polyglutamine cytosine–adenine …
neurodegenerative disorder caused by an expanded polyglutamine cytosine–adenine …
Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies1
L WANG, Z QIN - Acta pharmacologica sinica, 2006 - Wiley Online Library
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, which is
caused by an abnormal expansion of Cytosine Adenine Guanine (CAG) trinucleotide repeat …
caused by an abnormal expansion of Cytosine Adenine Guanine (CAG) trinucleotide repeat …
Mouse models of Huntington disease: variations on a theme
DE Ehrnhoefer, SL Butland… - Disease models & …, 2009 - journals.biologists.com
An accepted prerequisite for clinical trials of a compound in humans is the successful
alleviation of the disease in animal models. For some diseases, however, successful …
alleviation of the disease in animal models. For some diseases, however, successful …
Experimental models of HD and reflection on therapeutic strategies
J Kim, OL Bordiuk, RJ Ferrante - International review of neurobiology, 2011 - Elsevier
Huntington's disease (HD) is an autosomal dominant, progressive, and fatal
neurodegenerative disorder caused by an expanded polyglutamine cytosine–adenine …
neurodegenerative disorder caused by an expanded polyglutamine cytosine–adenine …
Mouse models for validating preclinical candidates for Huntington's disease
XW Yang, M Gray - … of Huntington's Disease: Applications to Drug …, 2011 - books.google.com
Ever since its original description by George Huntington in 1872, Huntington's disease (HD)
has been known as one of the most devastating inherited neurodegenerative disorders …
has been known as one of the most devastating inherited neurodegenerative disorders …
Surveying the landscape of Huntington's disease mechanisms, measurements, and medicines
ZR Crook, DE Housman - Journal of Huntington's disease, 2013 - content.iospress.com
Though 20 years have now passed since the cloning of the huntingtin gene (HTT), there
remains no treatment for Huntington's Disease (HD) that alters the course of disease or …
remains no treatment for Huntington's Disease (HD) that alters the course of disease or …