Role of oxidized phospholipids in cardiovascular pathology

D Allen, D Hasanally, A Ravandi - Clinical Lipidology, 2013 - Taylor & Francis
Long thought of as a bystander in pathophysiological processes, lipid molecules have
emerged as bioactive mediators of cardiovascular pathology. There has been accumulating …

Role of phospholipid oxidation products in atherosclerosis

S Lee, KG Birukov, CE Romanoski… - Circulation …, 2012 - Am Heart Assoc
There is increasing clinical evidence that phospholipid oxidation products (Ox-PL) play a
role in atherosclerosis. This review focuses on the mechanisms by which Ox-PL interact with …

Inflammatory profile of oxidized phospholipids

VN Bochkov - Thrombosis and haemostasis, 2007 - thieme-connect.com
Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly
recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL …

Oxidized phospholipids in cardiovascular disease

S Tsimikas, JL Witztum - Nature Reviews Cardiology, 2024 - nature.com
Prolonged or excessive exposure to oxidized phospholipids (OxPLs) generates chronic
inflammation. OxPLs are present in atherosclerotic lesions and can be detected in plasma …

The role of phospholipid oxidation products in inflammatory and autoimmune diseases: Evidence from animal models and in humans

N Leitinger - Lipids in Health and Disease, 2008 - Springer
Since the discovery of oxidized phospholipids (OxPL) and their implication as modulators of
inflammation in cardiovascular disease, roles for these lipid oxidation products have been …

[HTML][HTML] Oxidized phospholipids: introduction and biological significance

MZ Ashraf, S Srivastava - Lipoproteins-Role in Health and …, 2012 - intechopen.com
Phospholipids containing polyunsaturated fatty acids are highly prone to modification by
reactive oxygen species. They tend to undergo lipid peroxidation to form OxPLs which …

Oxidised phospholipids as biomarkers in human disease

M Philippova, T Resink, P Erne, V Bochkov - Swiss medical weekly, 2014 - smw.ch
Oxidised phospholipids (OxPLs) are generated from (poly) unsaturated diacyl-and alk (en)
ylacyl glycerophospholipids under conditions of oxidative stress. OxPLs exert a wide variety …

[HTML][HTML] The role of oxidized phospholipids in atherosclerosis

JA Berliner, N Leitinger, S Tsimikas - Journal of lipid research, 2009 - ASBMB
There is increasing evidence that oxidized phospholipids (OxPLs) play an important role in
atherosclerosis. These phospholipids accumulate in human and mouse lesions. Specific …

[HTML][HTML] Pleiotropic effects of oxidized phospholipids

V Bochkov, B Gesslbauer, C Mauerhofer… - Free Radical Biology …, 2017 - Elsevier
Oxidized phospholipids (OxPLs) are increasingly recognized to play a role in a variety of
normal and pathological states. OxPLs were implicated in regulation of inflammation …

The role of oxidized phospholipids in the development of disease

J Nie, J Yang, Y Wei, X Wei - Molecular aspects of medicine, 2020 - Elsevier
Oxidized phospholipids (OxPLs), complex mixtures of phospholipid oxidation products
generated during normal or pathological processes, are increasingly recognized to show …