Objectives: Estrogen is suggested to participate in pathogenesis of irritable bowel syndrome
(IBS), but expression of G protein-coupled estrogen receptor (GPER) in the colon of IBS …

The regulatory role of estrogens and nuclear estrogen receptors, ie, estrogen receptor α and
β has been reported in gastrointestinal diseases. However, the contribution of G protein …

Background Diarrhea‐predominant irritable bowel syndrome (IBS‐D) is a functional
gastrointestinal (GI) disorder, which occurs more frequently in women than men. The aim of …

The etiology and pathogenesis underlying irritable bowel syndrome (IBS), a common
gastrointestinal disorder are still unclear. Cumulating data suggest dysregulation of …

The pathogenesis of inflammatory bowel diseases (IBD) seems to be associated with
alterations of immunoregulation. Several lines of evidence suggest that estrogens play a …

Estrogens exert immunomodulatory action in many autoimmune diseases. Accumulating
evidence highlights the meaningful impact of estrogen receptors in physiology and …

Estrogens play important roles in the development and progression of multiple tumor types.
Accumulating evidence points to the significance of estrogen action not only in tumors of …

Visceral hypersensitivity (VH) is common in irritable bowel syndrome (IBS), and female
patients are more likely to seek healthcare services for IBS‐related abdominal pain …

Objective. To compare the expression of G‐protein‐coupled estrogen receptor (GPER) in
the junctional zone and outer myometrium of the proliferative and secretory phases of …

The aim of this study was to investigate the mechanism (s) of action of gastrointestinal
hormones in the pathogenesis of irritable bowel syndrome (IBS), and the correlation …