Abstract Background and Objectives Therapeutic hypothermia can influence the
pharmacokinetics and pharmacodynamics of drugs, the discipline which is called …

Objective: Phenobarbital is the first-line treatment for neonatal seizures. Many neonates with
hypoxic ischemic encephalopathy are treated with therapeutic hypothermia, and about 40 …

Purpose: Therapeutic hypothermia has recently been introduced to treat term newborns with
hypoxic–ischemic encephalopathy, of whom more than half have seizures. Phenobarbital is …

Abstract Background In the Netherlands, perinatal asphyxia (severe perinatal oxygen
shortage) necessitating newborn resuscitation occurs in at least 200 of the 180–185.000 …

Background Neonatal hypoxic ischaemic encephalopathy due to perinatal asphyxia, can
result in severe neurodevelopmental disability or mortality. Hypothermia is at present the …

Background: Phenobarbital and midazolam are commonly used drugs in (near-) term
neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for …

Examples of clinical applications of therapeutic hypothermia in modern clinical medicine
include traumatic cardiac arrest, ischaemic stroke and, more recently, acute perinatal …

Neonatal seizures constitute the most frequent presenting neurologic sign encountered in
the neonatal intensive care unit. Despite limited efficacy and safety data, phenobarbital …

Therapeutic hypothermia (HT) is frequently used in neonates with hypoxic-ischemic
encephalopathy and young infants during cardiopulmonary bypass (CPB). Hypothermia and …

With mounting evidence that hypothermia is neuroprotective in newborns with hypoxic-
ischemic encephalopathy (HIE), an increasing number of centers are offering this therapy …