Comparative genomics provides insights into molecular adaptation to hypermetamorphosis and cantharidin metabolism in blister beetles (Coleoptera: Meloidae)

A Riccieri, L Spagoni, M Li, P Franchini… - Integrative …, 2024 - Wiley Online Library
Abstract Blister beetles (Coleoptera: Meloidae) are currently subdivided into three
subfamilies: Eleticinae (a basal group), Nemognathinae, and Meloinae. These are all …

Unraveling the role of male reproductive tract and haemolymph in cantharidin-exuding Lydus trimaculatus and Mylabris variabilis (Coleoptera: Meloidae): a …

E Fratini, M Salvemini, F Lombardo, M Muzzi, M Molfini… - BMC genomics, 2021 - Springer
Background Meloidae (blister beetles) are known to synthetize cantharidin (CA), a toxic and
defensive terpene mainly stored in male accessory glands (MAG) and emitted outward …

The first chromosome‐level genome assembly and transcriptome sequencing provide insights into cantharidin production of the blister beetles

C Zhou, X Zheng, L Wang, B Yue, C DU… - Integrative …, 2024 - Wiley Online Library
Abstract Blister beetles (Coleoptera: Meloidae) produce a natural defensive toxin
cantharidin (CTD), which has been used for various cancer treatments and other diseases …

Draft Genome of a Blister Beetle Mylabris aulica

DL Guan, XQ Hao, D Mi, J Peng, Y Li, JY Xie… - Frontiers in …, 2020 - frontiersin.org
Mylabris aulica is a widely distributed blister beetle of the Meloidae family. It has the ability to
synthesize a potent defensive secretion that includes cantharidin, a toxic compound used to …

De novo transcriptome and expression profile analysis to reveal genes and pathways potentially involved in cantharidin biosynthesis in the blister beetle Mylabris …

Y Huang, Z Wang, S Zha, Y Wang, W Jiang, Y Liao… - PLoS …, 2016 - journals.plos.org
The dried body of Mylabris cichorii is well-known Chinese traditional medicine. The
sesquiterpenoid cantharidin, which is secreted mostly by adult male beetles, has recently …

Functional studies of McSTE24, McCYP305a1, and McJHEH, three essential genes act in cantharidin biosynthesis in the blister beetle (Coleoptera: Meloidae)

Y Huang, L Shen, F Du, Z Wang… - Journal of Insect …, 2024 - academic.oup.com
Cantharidin is a toxic defensive substance secreted by most blister beetles when attacked. It
has been used to treat many complex diseases since ancient times and has recently …

Cantharidin is conserved across phylogeographic lineages and present in both morphs of Iberian Berberomeloe blister beetles (Coleoptera, Meloidae)

C Bravo, P Mas-Peinado, LM Bautista… - Zoological Journal of …, 2017 - academic.oup.com
Intra-specific coloration polymorphism coupled with an ancient process of lineage
differentiation in Berberomeloe majalis (Linnaeus, 1758) offers the opportunity to analyse …

Draft genomes of two blister beetles Hycleus cichorii and Hycleus phaleratus

YM Wu, J Li, XS Chen - Gigascience, 2018 - academic.oup.com
Background Commonly known as blister beetles or Spanish fly, there are more than 1500
species in the Meloidae family (Hexapoda: Coleoptera: Tenebrionoidea) that produce the …

De novo transcriptome assemblies of Epicauta tibialis provide insights into the sexual dimorphism in the production of cantharidin

C Du, W Li, Z Fu, C Yi, X Liu… - Archives of Insect …, 2021 - Wiley Online Library
Blister beetles have medicinal uses for their defensive secretion cantharidin, which has
curative effects on many cancers and other diseases. It was demonstrated that sexual …

Draft genome of the blister beetle, Epicauta chinensis

X Tian, X Su, C Li, Y Zhou, S Li, J Guo, Q Fan… - International journal of …, 2021 - Elsevier
Existence of cantharidin (CTD) in blister beetles is a significant ecological adaptive
mechanism that defends against predators and regulates courtship and mating behaviors …