Delineation of molecular lesions in acute myeloid leukemia patients at diagnosis: integrated next generation sequencing and cytogenomic studies
SM Papuc, A Erbescu, D Cisleanu, D Ozunu, C Enache… - Genes, 2021 - mdpi.com
Acute myeloid leukemia (AML) is a heterogeneous disorder characterized by a wide range
of genetic defects. Cytogenetics, molecular and genomic technologies have proved to be …
of genetic defects. Cytogenetics, molecular and genomic technologies have proved to be …
Next-generation sequencing reveals gene mutations landscape and clonal evolution in patients with acute myeloid leukemia
X Chen, H Zhu, C Qiao, S Zhao, L Liu, Y Wang, H Jin… - …, 2021 - Taylor & Francis
Objectives: The study aims to understand geneome diversification and complexity that
developed in Acute myeloid leukemia (AML). Methods: Next-generation sequencing (NGS) …
developed in Acute myeloid leukemia (AML). Methods: Next-generation sequencing (NGS) …
Validation of a new NGS-based myeloid panel in acute myeloid leukemia: A single-center experience
Acute myeloid leukemia (AML) identifies a heterogeneous group of clonal disorders, both
clinically and genetically. A large number of mutations have been described in AML …
clinically and genetically. A large number of mutations have been described in AML …
Next generation sequencing of acute myeloid leukemia: influencing prognosis
Acute myeloid leukemia (AML) is a clonal disorder of the blood forming cells characterized
by accumulation of immature blast cells in the bone marrow and peripheral blood. Being a …
by accumulation of immature blast cells in the bone marrow and peripheral blood. Being a …
Genetic landscape of acute myeloid leukemia interrogated by next-generation sequencing: a large cancer center experience
MO Hussaini, AS Mirza, R Komrokji… - Cancer genomics & …, 2018 - cgp.iiarjournals.org
Background/Aim: Acute myeloid leukemia (AML) represents a heterogeneous disease with
varying morphologic, immunophenotypic, and genetic features, along with varying patient …
varying morphologic, immunophenotypic, and genetic features, along with varying patient …
Comprehensive prospective next generation sequencing of acute myeloid leukemia
C Orsmark-Pietras, H Lilljebjörn, M Rissler, V Lazarevic… - 2015 - ashpublications.org
Abstract Acute Myeloid Leukemia (AML) is a heterogeneous disease with poor overall five-
year survival of less than 30%. Current risk stratification is largely based on cytogenetics …
year survival of less than 30%. Current risk stratification is largely based on cytogenetics …
Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing
Y Li, X Lv, X Ge, D Yuan, M Ding… - Molecular …, 2019 - spandidos-publications.com
The aim of the present study was to examine the associations between 112 acute myeloid
leukaemia (AML)‑associated genes and the prognosis and clinical features of AML using …
leukaemia (AML)‑associated genes and the prognosis and clinical features of AML using …
Mutation profile of acute myeloid leukaemia in a Chinese cohort by targeted next‐generation sequencing
BMW Lit, BB Guo, JAJ Malherbe, YL Kwong… - Cancer …, 2022 - Wiley Online Library
Background Acute myeloid leukaemia (AML) results from the clonal expansion of blast cells
of myeloid origin driven by genomic defects. The advances in next‐generation sequencing …
of myeloid origin driven by genomic defects. The advances in next‐generation sequencing …
Comprehensive Molecular Profiling of NPM1-Mutated Acute Myeloid Leukemia Using RNAseq Approach
J Petiti, Y Pignochino, A Schiavon, E Giugliano… - International Journal of …, 2024 - mdpi.com
Acute myeloid leukemia (AML) is a complex hematologic malignancy with high morbidity
and mortality. Nucleophosmin 1 (NPM1) mutations occur in approximately 30% of AML …
and mortality. Nucleophosmin 1 (NPM1) mutations occur in approximately 30% of AML …
New molecular abnormalities and clonal architecture in AML: from reciprocal translocations to whole-genome sequencing
TA Graubert, AM Brunner, AT Fathi - American Society of Clinical …, 2014 - ascopubs.org
Acute myeloid leukemia (AML) is characterized by recurrent genetic alterations, including
amplifications, deletions, rearrangements, and point mutations. Clinically, these lesions can …
amplifications, deletions, rearrangements, and point mutations. Clinically, these lesions can …