Delineation of molecular lesions in acute myeloid leukemia patients at diagnosis: integrated next generation sequencing and cytogenomic studies

SM Papuc, A Erbescu, D Cisleanu, D Ozunu, C Enache… - Genes, 2021 - mdpi.com
Acute myeloid leukemia (AML) is a heterogeneous disorder characterized by a wide range
of genetic defects. Cytogenetics, molecular and genomic technologies have proved to be …

Next-generation sequencing reveals gene mutations landscape and clonal evolution in patients with acute myeloid leukemia

X Chen, H Zhu, C Qiao, S Zhao, L Liu, Y Wang, H Jin… - …, 2021 - Taylor & Francis
Objectives: The study aims to understand geneome diversification and complexity that
developed in Acute myeloid leukemia (AML). Methods: Next-generation sequencing (NGS) …

Validation of a new NGS-based myeloid panel in acute myeloid leukemia: A single-center experience

C Steidl, A Aroldi, L Mologni, I Crespiatico, D Fontana… - Leukemia Research, 2022 - Elsevier
Acute myeloid leukemia (AML) identifies a heterogeneous group of clonal disorders, both
clinically and genetically. A large number of mutations have been described in AML …

Next generation sequencing of acute myeloid leukemia: influencing prognosis

AM Ilyas, S Ahmad, M Faheem, MI Naseer… - BMC genomics, 2015 - Springer
Acute myeloid leukemia (AML) is a clonal disorder of the blood forming cells characterized
by accumulation of immature blast cells in the bone marrow and peripheral blood. Being a …

Genetic landscape of acute myeloid leukemia interrogated by next-generation sequencing: a large cancer center experience

MO Hussaini, AS Mirza, R Komrokji… - Cancer genomics & …, 2018 - cgp.iiarjournals.org
Background/Aim: Acute myeloid leukemia (AML) represents a heterogeneous disease with
varying morphologic, immunophenotypic, and genetic features, along with varying patient …

Comprehensive prospective next generation sequencing of acute myeloid leukemia

C Orsmark-Pietras, H Lilljebjörn, M Rissler, V Lazarevic… - 2015 - ashpublications.org
Abstract Acute Myeloid Leukemia (AML) is a heterogeneous disease with poor overall five-
year survival of less than 30%. Current risk stratification is largely based on cytogenetics …

Mutational spectrum and associations with clinical features in patients with acute myeloid leukaemia based on next‑generation sequencing

Y Li, X Lv, X Ge, D Yuan, M Ding… - Molecular …, 2019 - spandidos-publications.com
The aim of the present study was to examine the associations between 112 acute myeloid
leukaemia (AML)‑associated genes and the prognosis and clinical features of AML using …

Mutation profile of acute myeloid leukaemia in a Chinese cohort by targeted next‐generation sequencing

BMW Lit, BB Guo, JAJ Malherbe, YL Kwong… - Cancer …, 2022 - Wiley Online Library
Background Acute myeloid leukaemia (AML) results from the clonal expansion of blast cells
of myeloid origin driven by genomic defects. The advances in next‐generation sequencing …

Comprehensive Molecular Profiling of NPM1-Mutated Acute Myeloid Leukemia Using RNAseq Approach

J Petiti, Y Pignochino, A Schiavon, E Giugliano… - International Journal of …, 2024 - mdpi.com
Acute myeloid leukemia (AML) is a complex hematologic malignancy with high morbidity
and mortality. Nucleophosmin 1 (NPM1) mutations occur in approximately 30% of AML …

New molecular abnormalities and clonal architecture in AML: from reciprocal translocations to whole-genome sequencing

TA Graubert, AM Brunner, AT Fathi - American Society of Clinical …, 2014 - ascopubs.org
Acute myeloid leukemia (AML) is characterized by recurrent genetic alterations, including
amplifications, deletions, rearrangements, and point mutations. Clinically, these lesions can …