Embryonic MTHFR contributes to blastocyst development
H Ishitani, S Ikeda, K Egashira, M Sugimoto… - Journal of Assisted …, 2020 - Springer
Purpose Reduction in methylenetetrahydrofolate reductase (MTHFR) activity due to genetic
variations in the MTHFR gene has been controversially implicated in subfertility in human in …
variations in the MTHFR gene has been controversially implicated in subfertility in human in …
Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy
M Enciso, J Sarasa, L Xanthopoulou, S Bristow… - Human genetics, 2016 - Springer
MTHFR is an important enzyme in the metabolism of folic acid and is crucial for reproductive
function. Variation in the sequence of MTHFR has been implicated in subfertility, but …
function. Variation in the sequence of MTHFR has been implicated in subfertility, but …
Methylenetetrahydrofolate reductase gene polymorphisms are not associated with embryo chromosomal abnormalities and IVF outcomes
R Morales, B Lledó, JA Ortiz, A Cascales… - Systems Biology in …, 2021 - Taylor & Francis
The aim of our study was to investigate the effect of maternal and embryo MTHFR C677T
and A1298C polymorphisms on embryo aneuploidies and mosaicism and the correlation …
and A1298C polymorphisms on embryo aneuploidies and mosaicism and the correlation …
[HTML][HTML] Maternal Mthfd1 disruption impairs fetal growth but does not cause neural tube defects in mice
AE Beaudin, CA Perry, SP Stabler, RH Allen… - The American journal of …, 2012 - Elsevier
Background: MTHFD1 encodes C1-tetrahydrofolate synthase, which is a folate-dependent
enzyme that catalyzes the formation and interconversion of folate-activated one-carbon …
enzyme that catalyzes the formation and interconversion of folate-activated one-carbon …
Human MTHFR-G1793A transition may be a protective mutation against male infertility: a genetic association study and in silico analysis
M Karimian, A Hosseinzadeh Colagar - Human Fertility, 2018 - Taylor & Francis
In this paper, we evaluate the association of the human methylenetetrahydrofolate reductase
(MTHFR)-G1793A transition with male infertility using a case-control study, a meta-analysis …
(MTHFR)-G1793A transition with male infertility using a case-control study, a meta-analysis …
Association of MTHFR 677C> T polymorphism with pregnancy outcomes in IVF/ICSI-ET recipients with adequate synthetic folic acid supplementation
F Ye, S Zhang, Q Qi, J Zhou, Y Du, L Wang - BioScience Trends, 2022 - jstage.jst.go.jp
Folic acid (FA) is an important type of vitamin B, which is involved in various biological
transmethylation reactions that include many physiological and pathological processes …
transmethylation reactions that include many physiological and pathological processes …
Folate-mediated one-carbon metabolism and its effect on female fertility and pregnancy viability
M Laanpere, S Altmäe, A Stavreus-Evers… - Nutrition …, 2010 - academic.oup.com
This review summarizes current knowledge of the effect of folate-mediated one-carbon
metabolism and related genetic variants on female fertility and pregnancy viability …
metabolism and related genetic variants on female fertility and pregnancy viability …
Photoperiod at conception predicts C677T‐MTHFR genotype: A novel gene‐environment interaction
M Lucock, T Glanville, L Ovadia, Z Yates… - American Journal of …, 2010 - Wiley Online Library
Data is presented, which suggest that the day length a woman experiences during the
periconceptional period predicts the C677T‐MTHFR genotype of her child. Logistic …
periconceptional period predicts the C677T‐MTHFR genotype of her child. Logistic …
High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory …
RH Bahous, NM Jadavji, L Deng… - Human molecular …, 2017 - academic.oup.com
Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for
methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic …
methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic …
Association of homocysteine with IVF/ICSI outcomes stratified by MTHFR C677T polymorphisms: a prospective cohort study
L Chen, H Chen, X Wang, B Wei, Z Wu, S Chen… - Reproductive …, 2021 - Elsevier
Research question What is the association between homocysteine (Hcy) and
IVF/intracytoplasmic sperm injection (ICSI) outcomes, stratified by methylenetetrahydrofolate …
IVF/intracytoplasmic sperm injection (ICSI) outcomes, stratified by methylenetetrahydrofolate …