Research question What is the association between homocysteine (Hcy) and
IVF/intracytoplasmic sperm injection (ICSI) outcomes, stratified by methylenetetrahydrofolate …

Background Suboptimal folate intake, a risk factor for birth defects, is common even in areas
with folate fortification. A polymorphism in methylenetetrahydrofolate dehydrogenase 1 …

STUDY QUESTION What are the roles of maternal 5, 10-methylenetetrahydrofolate
reductase (MTHFR) C677T/A1298C combination polymorphisms on the embryological and …

Homocysteine is known to be associated with adverse vascular and metabolic effects, as
well as pregnancy complications. Its serum levels are influenced by the function of the …

5-methyltetrahydrofolate (5-MTHF), or its synthetic precursor, folic acid, is traditionally used
as a supplement for improving fertility and for the prevention of embryonal neural tube …

The aim of this study was to investigate the association between MTHFR gene
polymorphisms and IVF outcomes in Brazilian women undergoing assisted reproduction …

The process of methylation is a major biochemical component of all cells, essential in
allowing covalent linking of methyl groups to lipids, proteins, and nucleic acids. It is involved …

BACKGROUND Folic acid fortification and supplementation has increased folate intake and
blood folate concentrations and successfully reduced the incidence of neural tube defects …

Background: Moderately high folic acid intake in pregnant women has led to concerns about
deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such …

BACKGROUND: There is concern that IVF could compromise normal imprinting and
methylation of DNA. Methylenetetrahydrofolate reductase (MTHFR) regulates the flow of folic …