Objective: This research explored the expression of MTHFR gene polymorphism and
homocysteine (Hcy) in spontaneous abortions in pregnant women. Methods: Eighty-two …

The etiology and degree of clinical symptoms of preeclampsia depend on genotypic and
phenotypic maternal and trophoblast factors, and elevated levels of plasma homocysteine …

Background: Genetic or nutritional disturbances in folate metabolism may affect embryonic
development because of the critical role of folate in nucleotide synthesis and methylation …

Abnormal uptake or metabolism of folate increases risk of human pregnancy complications,
though the mechanism is unclear. Here, we explore how defective folate metabolism …

Supplementation with high doses of folic acid, an important mediator of one-carbon transfers
for DNA methylation, is used clinically to improve sperm parameters in infertile men. We …

Key points Folate deficiency during pregnancy is associated with restricted fetal growth,
although the underlying mechanisms are poorly understood. Here we show that mechanistic …

Abstract Early-Gestational Diabetes Mellitus (Early-GDM) is a complex condition that may
cause complications in infants of affected mothers. The aim of this case–control study was to …

Objective To study folic acid intake, folate status and pregnancy outcome after infertility
treatment in women with different infertility diagnoses in relation to …

Birth defects are common, serious malformations with a complex etiology that suggests
involvement of both genetic and environmental factors. Low dietary folate and …

Folic acid and methylenetetrahydrofolate reductase enzyme (MTHFR) gene C677T
(rs1801133) SNP have been proofed to influence the spermatogenesis. This study aimed to …