Gene-based therapeutics has emerged as a promising approach for human cancer therapy.
Among a variety of non-viral vectors, polymer vectors are particularly attractive due to their …

Nanoparticle-mediated small interfering RNA (siRNA) delivery is a promising therapeutic
strategy in various cancers. However, it is difficult to deliver degradative siRNA to tumor …

Delivery of small interfering RNAs (siRNAs) into cells still remains a challenge in gene
delivery studies. Here, we investigated the ability of synthesized Fe 3 O 4-PEG-LAC …

Recently, survivin has been attracting great attention because it plays an important role in
inhibiting the apoptosis process of tumor cells. Down-regulating the expression of survivin …

The limited effectiveness of the conventional methods for cancer treatment makes the
researchers to find novel safe and effective therapeutic strategies. One of these strategies is …

Melanoma anti-tumor therapy remains a challenge. SiRNA-based therapies provide a
powerful means, but limitations remain in its pharmaceutical applications owing to the lack of …

As a gene delivery method in breast cancer therapy, knocking down the undesired genes in
the cancerous cells would be promising. Inhibitors of Apoptosis Protein (IAP) family genes …

This study developed a pH-sensitive anionic system composed of guanidinylated O-
carboxymethyl chitosan (GOCMCS) and N-2-hydroxypropyltimehyl ammonium chloride …

The effect of gene silencing by survivin siRNA (siSurvivin) on the proliferation and apoptosis
of lung tumor has been attracted more interest. GABA B receptor ligand-directed …

Purpose Chitosan, a natural and biocompatible cationic polymer, is an attractive carrier for
small interfering RNA (siRNA) delivery. The purpose of this study was to develop a chitosan …