Curcumin induces re-expression of BRCA1 and suppression of γ synuclein by modulating DNA promoter methylation in breast cancer cell lines

N Al-Yousef, Z Shinwari, B Al-Shahrani… - Oncology …, 2020 - spandidos-publications.com
Restoration of normal DNA promoter methylation and expression states of cancer-related
genes may be an option for the prevention as well as the treatment of several types of …

Curcumin‐induced DNA demethylation in human gastric cancer cells is mediated by the DNA‐damage response pathway

R Tong, X Wu, Y Liu, Y Liu, J Zhou… - Oxidative medicine …, 2020 - Wiley Online Library
Curcumin, a natural polyphenol antioxidant extracted from the root of turmeric (Curcuma
longa), can induce apoptosis and DNA demethylation in several types of cancer cells …

Curcumin from turmeric rhizome: A potential modulator of DNA methylation machinery in breast cancer inhibition

K Fabianowska-Majewska, A Kaufman-Szymczyk… - Nutrients, 2021 - mdpi.com
One of the most systematically studied bioactive nutraceuticals for its benefits in the
management of various diseases is the turmeric-derived compounds: curcumin. Turmeric …

Reactivation of RASSF1A in breast cancer cells by curcumin

L Du, Z Xie, L Wu, M Chiu, J Lin, KK Chan… - Nutrition and …, 2012 - Taylor & Francis
Reactivation of tumor suppressor genes (TSGs) involved in carcinogenesis by nontoxic
bioactive food component represents a promising strategy for cancer chemoprevention …

Curcumin induces DNA damage by mediating homologous recombination mechanism in triple negative breast cancer

G Guney Eskiler, E Sahin, A Deveci Ozkan… - Nutrition and …, 2020 - Taylor & Francis
Curcumin has a therapeutic potential activity through modulation of different signaling
pathways in various types of cancer. However, the relationship between the efficacy of …

[PDF][PDF] Curcumin-mediated reversal of p15 gene promoter methylation: implication in anti-neoplastic action against acute lymphoid leukaemia cell line

V Sharma, AK Jha, A Kumar, A Bhatnagar, G Narayan… - Folia biologica, 2015 - fb.cuni.cz
Curcumin has been documented to exert anticancer effects by interacting with altered
proliferative and apoptotic pathways in cancer models. In this study, we evaluated the …

Epigenetic CpG demethylation of the promoter and reactivation of the expression of Neurog1 by curcumin in prostate LNCaP cells

L Shu, TO Khor, JH Lee, SSS Boyanapalli, Y Huang… - The AAPS journal, 2011 - Springer
Curcumin (CUR), a major bioactive polyphenolic component from turmeric curry, Curcuma
longa, has been shown to be a potent anti-cancer phytochemical with well-established anti …

Curcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia

J Yu, Y Peng, LC Wu, Z Xie, Y Deng, T Hughes, S He… - PloS one, 2013 - journals.plos.org
Bioactive components from dietary supplements such as curcumin may represent attractive
agents for cancer prevention or treatment. DNA methylation plays a critical role in acute …

[HTML][HTML] Curcumin: An epigenetic regulator and its application in cancer

T Ming, Q Tao, S Tang, H Zhao, H Yang, M Liu… - Biomedicine & …, 2022 - Elsevier
Nowadays, one of the leading causes of death in humans is cancer, which is still on the rise
globally and is in great need of intense study on the pathogenic mechanism and effective …

Curcumin and dimethoxycurcumin induced epigenetic changes in leukemia cells

HE Hassan, S Carlson, I Abdallah, T Buttolph… - Pharmaceutical …, 2015 - Springer
Purpose Curcumin is an ideal chemopreventive and antitumor agent characterized by poor
bioavailability and low stability. The development of synthetic structural analogues like …