Uric acid is a common metabolite found in mammals' serum. Recently, several metabolites
have been identified that modulate aging, and uric acid levels are positively correlated with …

Cytokinins are phytohormones that are involved in many processes in plants, including
growth, differentiation and leaf senescence. However, they also have various activities in …

Accumulation of senescent cells may drive age-associated alterations and pathologies.
Senolytics are promising therapeutics that can preferentially eliminate senescent cells. Here …

Current ageing research is aimed not only at the promotion of longevity, but also at
improving‎ health span‎ through the‎ discovery and development‎ of new therapeutic strategies‎‏‎ …

Dietary restriction (DR) is a robust non-genetic intervention that reduces morbidity and
mortality in a range of organisms. This suggests the presence of an evolutionary-conserved …

Life expectancy at the turn of the 20th century was 46 years on average worldwide and it is
around 65 years today. The correlative increase in age‐associated diseases incidence has …

The beneficial effects of polyphenol compounds in fruits and vegetables are mainly
extrapolated from in vitro studies or short‐term dietary supplementation studies. Due to cost …

Scope Vitexin and isovitexin are natural plant nutraceuticals for human health and longevity.
This research investigates the underlying mechanisms of vitexin and isovitexin on aging and …

It was recently reported that the plant polyphenol resveratrol, found, eg, in grape berry skins,
extended lifespan in the fruit fly Drosophila melanogaster and the nematode worm …

The root of Rhodiola rosea is widely used in Traditional Chinese Medicine. The extract from
R. rosea is reported to extend the lifespan of yeast, nematode, and fruit fly. However, the …