Background Subjective effects of cocaine are mediated primarily by dopamine (DA)
transporter (DAT) blockade. The present study assessed the hypothesis that different DAT …

Typical and atypical dopamine uptake inhibitors (DUIs) prefer distinct conformations of the
dopamine transporter (DAT) to form ligand-transporter complexes, resulting in markedly …

Rationale Dopamine transporter (DAT) conformation plays a role in the effectiveness of
cocaine-like and other DAT inhibitors. Cocaine-like stimulants are intolerant to DAT …

A major theme of addiction research has focused on the neural substrates of individual
differences in the risk for addiction; however, little is known about how vulnerable …

Medication-assisted treatments are unavailable to patients with cocaine use disorders.
Efforts to develop potential pharmacotherapies have led to the identification of a promising …

Cocaine is a commonly abused central nervous system stimulant that enhances dopamine
(DA) neurotransmission through its ability to block dopamine transporters (DAT s). Recent …

The dopamine transporter (DAT) is responsible for terminating dopamine (DA) signaling and
is the primary site of cocaine's reinforcing actions. Cocaine self-administration has been …

Drugs that target the dopamine transporter (DAT) have been proposed as
pharmacotherapies to treat cocaine abuse. Accordingly, it is paramount to understand …

Although there are no Food and Drug Administration–approved treatments for cocaine use
disorder, several modafinil analogs have demonstrated promise in reducing cocaine self …

A number of studies over the last two decades have demonstrated the critical importance of
dopamine (DA) in the behavioral pharmacology and addictive properties of abused drugs …