Restoring airway function in muco-obstructive diseases by modulating TMEM16A and SLC26A9
R Martins Centeio - 2023 - epub.uni-regensburg.de
Human airways are permanently exposed to the external environment, which contains a
myriad of noxious agents such as pathogens, sterile irritants, and allergens. The airway …
myriad of noxious agents such as pathogens, sterile irritants, and allergens. The airway …
[PDF][PDF] Restoring Airway Function in Muco-obstructive Diseases by Modulating TMEM16A and SLC26A9
RM Centeio - 2022 - scholar.archive.org
Human airways are permanently exposed to the external environment, which contains a
myriad of noxious agents such as pathogens, sterile irritants, and allergens. The airway …
myriad of noxious agents such as pathogens, sterile irritants, and allergens. The airway …
Pharmacological Inhibition and Activation of the Ca2+ Activated Cl− Channel TMEM16A
R Centeio, I Cabrita, R Benedetto, K Talbi… - International journal of …, 2020 - mdpi.com
TMEM16A is a Ca2+ activated Cl− channel with important functions in airways, intestine,
and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic …
and other epithelial organs. Activation of TMEM16A is proposed as a therapy in cystic …
Mucus release and airway constriction by TMEM16A may worsen pathology in inflammatory lung disease
R Centeio, J Ousingsawat, I Cabrita… - International journal of …, 2021 - mdpi.com
Activation of the Ca2+ activated Cl− channel TMEM16A is proposed as a treatment in
inflammatory airway disease. It is assumed that activation of TMEM16A will induce …
inflammatory airway disease. It is assumed that activation of TMEM16A will induce …
CLCA1 Regulates Airway Mucus Production and Ion Secretion Through TMEM16A
K Kunzelmann, R Centeio… - International …, 2021 - epub.uni-regensburg.de
TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …
CLCA1 regulates airway mucus production and ion secretion through TMEM16A
R Centeio, J Ousingsawat, R Schreiber… - International journal of …, 2021 - mdpi.com
TMEM16A, a Ca2+-activated chloride channel (CaCC), and its regulator, CLCA1, are
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …
associated with inflammatory airway disease and goblet cell metaplasia. CLCA1 is a …
[HTML][HTML] Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction
H Danahay, R Fox, S Lilley, H Charlton… - FASEB …, 2020 - ncbi.nlm.nih.gov
The calcium‐activated chloride channel (CaCC) TMEM16A enables chloride secretion
across several transporting epithelia, including in the airways. Additional roles for TMEM16A …
across several transporting epithelia, including in the airways. Additional roles for TMEM16A …
TMEM16A mediates mucus production in human airway epithelial cells
I Cabrita, R Benedetto, P Wanitchakool… - American journal of …, 2021 - atsjournals.org
TMEM16A is a Ca2+-activated chloride channel that was shown to enhance production and
secretion of mucus in inflamed airways. It is, however, not clear whether TMEM16A directly …
secretion of mucus in inflamed airways. It is, however, not clear whether TMEM16A directly …
[HTML][HTML] Niclosamide repurposed for the treatment of inflammatory airway disease
I Cabrita, R Benedetto, R Schreiber, K Kunzelmann - JCI insight, 2019 - ncbi.nlm.nih.gov
Inflammatory airway diseases, such as asthma, cystic fibrosis (CF), and chronic obstructive
pulmonary disease (COPD), are characterized by mucus hypersecretion and airway …
pulmonary disease (COPD), are characterized by mucus hypersecretion and airway …
TMEM16A in cystic fibrosis: activating or inhibiting?
K Kunzelmann, J Ousingsawat, I Cabrita… - Frontiers in …, 2019 - frontiersin.org
The inflammatory airway disease cystic fibrosis (CF) is characterized by airway obstruction
due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis …
due to mucus hypersecretion, airway plugging, and bronchoconstriction. The cystic fibrosis …