[PDF][PDF] Sen1 is a key regulator of transcription-driven conflicts
U Aiello, D Challal, G Wentzinger, A Lengronne… - Molecular Cell, 2022 - cell.com
Cellular homeostasis requires the coordination of several machineries concurrently
engaged in the DNA. Wide-spread transcription can interfere with other processes, and …
engaged in the DNA. Wide-spread transcription can interfere with other processes, and …
[PDF][PDF] Yeast Sen1 helicase protects the genome from transcription-associated instability
Sen1 of S. cerevisiae is a known component of the NRD complex implicated in transcription
termination of nonpolyadenylated as well as some polyadenylated RNA polymerase II …
termination of nonpolyadenylated as well as some polyadenylated RNA polymerase II …
[PDF][PDF] Sen1 is recruited to replication forks via Ctf4 and Mrc1 and promotes genome stability
DNA replication and RNA transcription compete for the same substrate during S phase.
Cells have evolved several mechanisms to minimize such conflicts. Here, we identify the …
Cells have evolved several mechanisms to minimize such conflicts. Here, we identify the …
Dormant origins and fork protection mechanisms rescue sister forks arrested by transcription
The yeast RNA/DNA helicase Sen1, Senataxin in human, preserves the integrity of
replication forks encountering transcription by removing RNA-DNA hybrids. Here we show …
replication forks encountering transcription by removing RNA-DNA hybrids. Here we show …
[HTML][HTML] Senataxin associates with replication forks to protect fork integrity across RNA-polymerase-II-transcribed genes
Transcription hinders replication fork progression and stability. The ATR checkpoint and
specialized DNA helicases assist DNA synthesis across transcription units to protect …
specialized DNA helicases assist DNA synthesis across transcription units to protect …
Multiple protein/protein and protein/RNA interactions suggest roles for yeast DNA/RNA helicase Sen1p in transcription, transcription‐coupled DNA repair and RNA …
D Ursic, K Chinchilla, JS Finkel… - Nucleic acids …, 2004 - academic.oup.com
Sen1p in Saccharomyces cerevisiae is a Type I DNA/RNA helicase. Mutations in the
helicase domain perturb accumulation of diverse RNA classes, and Sen1p has been …
helicase domain perturb accumulation of diverse RNA classes, and Sen1p has been …
[PDF][PDF] Senataxin ortholog Sen1 limits DNA: RNA hybrid accumulation at DNA double-strand breaks to control end resection and repair fidelity
CC Rawal, L Zardoni, M Di Terlizzi, E Galati… - Cell reports, 2020 - cell.com
An important but still enigmatic function of DNA: RNA hybrids is their role in DNA double-
strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the …
strand break (DSB) repair. Here, we show that Sen1, the budding yeast ortholog of the …
Sen1, the yeast homolog of human senataxin, plays a more direct role than Rad26 in transcription coupled DNA repair
Rad26, a DNA dependent ATPase that is homologous to human CSB, has been well known
to play an important role in transcription coupled DNA repair (TCR) in the yeast …
to play an important role in transcription coupled DNA repair (TCR) in the yeast …
Elongating RNA polymerase II and RNA: DNA hybrids hinder fork progression and gene expression at sites of head-on replication-transcription collisions
L Zardoni, E Nardini, A Brambati, C Lucca… - Nucleic Acids …, 2021 - academic.oup.com
Uncoordinated clashes between replication forks and transcription cause replication stress
and genome instability, which are hallmarks of cancer and neurodegeneration. Here, we …
and genome instability, which are hallmarks of cancer and neurodegeneration. Here, we …
[PDF][PDF] Cell-cycle modulation of transcription termination factor Sen1
Many non-coding transcripts (ncRNA) generated by RNA polymerase II in S. cerevisiae are
terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are …
terminated by the Nrd1-Nab3-Sen1 complex. However, Sen1 helicase levels are …