[HTML][HTML] Antidepressant Effect of Alpha Lipoic Acid in Rats Exposed to Chronic Unpredictable Mild Stress: Putative Role of Neurotransmitters and 5HT3 Receptor

L Akotkar, U Aswar, R Patil, D Kumar, M Aswar… - Future …, 2023 - mdpi.com
Depression is a neuropsychiatric disorder characterized by altered emotion and cognition.
Alpha lipoic acid (ALA) is a potent natural antioxidant and exhibits neuroprotective effects …

Alpha-lipoic acid attenuates depressive symptoms in mice exposed to chronic unpredictable mild stress

Y Yusha'u, UA Muhammad, S Mustapha… - Journal of African …, 2021 - ajol.info
Background: Depression is the most common psychiatric illness that involves mood
disturbances affecting many brain regions. Despite many approaches available to treat …

Alpha-lipoic acid enhances short-term spatial memory of mice in open-space forced swim-induced depression mouse model

Y Yusha'u, UM Adam, AA Wahab… - Neuroscience …, 2021 - neuroscirn.org
Depression affects over 264 million people of all ages globally. Major depressive disorder
significantly and chronically reduced quality of life by its association with functional …

Dietary of n-3 polyunsaturated fatty acids influence neurotransmitter systems of rats exposed to unpredictable chronic mild stress

R Yang, MQ Zhang, Y Xue, R Yang, MM Tang - Behavioural Brain …, 2019 - Elsevier
Emerging evidence suggest that neuromodulators are the critical factor involved in
depression. This study aimed to investigate the effects of unpredictable chronic mild stress …

[PDF][PDF] Flaxseed oil (Linum usitatissimum) attenuates restraint stress-induced depressive-like behavior: Upregulation of neurotrophic factors in CA1 region of …

S Talei, T Mokhtari, I Asadi, L Arab… - Journal of Contemporary …, 2021 - iasj.net
Objective Depression results from oxidative and inflammatory neural damages caused by
life stressors. Flaxseed (FS) oil exerts antioxidant activity in various studies. In this study, we …

[HTML][HTML] Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2/HO-1/NLRP3 signaling in rat

H Bian, G Wang, J Huang, L Liang, Y Zheng… - Journal of …, 2020 - Springer
Background Recently, depression has been identified as a prevalent and severe mental
disorder. However, the mechanisms underlying the depression risk remain elusive. The …

[HTML][HTML] EPA is more effective than DHA to improve depression-like behavior, glia cell dysfunction and hippcampal apoptosis signaling in a chronic stress-induced rat …

Z Peng, C Zhang, L Yan, Y Zhang, Z Yang… - International journal of …, 2020 - mdpi.com
Clinical evidence indicated that eicosapentaenoic acid (EPA) was more effective than
docosahexaenoic acid (DHA) in depression treatment. However, possible mechanisms …

Modulatory effect of n-3 polyunsaturated fatty acids on depressive-like behaviors in rats with chronic sleep deprivation: potential involvement of melatonin receptor …

CH Chang, HC Wu, YR Hsieh, WD Lai, TH Tung… - Food & Function, 2023 - pubs.rsc.org
Clinical evidence suggests that a bidirectional relationship is present between sleep loss
and psychiatric disorders. Both melatonin receptor agonist ramelteon (RMT) and n-3 …

Linoleic Acid Derivative DCP-LA Ameliorates Stress-Induced Depression-Related Behavior by Promoting Cell Surface 5-HT1A Receptor Translocation, Stimulating …

T Kanno, A Tanaka, T Nishizaki - Molecular Neurobiology, 2015 - Springer
Impairment of serotonergic neurotransmission is the major factor responsible for depression
and glycogen synthase kinase 3β (GSK-3β) participates in serotonergic transmission …

[HTML][HTML] Antidepressant-like effects of omega-3 fatty acids in postpartum model of depression in rats

L Arbabi, MTH Baharuldin, MAM Moklas… - Behavioural brain …, 2014 - Elsevier
Postpartum depression (PPD) is a psychiatric disorder that occurs in 10–15% of
childbearing women. It is hypothesized that omega-3 fatty acids, which are components of …