Oxido-nitrosative stress, neuroinflammation, and reduced level of neurotrophins are
implicated in the pathophysiology of anxiety and depressive illness. A few recent studies …

Depression is a common worldwide mental disorder whose etiology remains unclear; there
is also a lack of effective therapeutic agents. Sodium valproate (VPA) is a traditional …

Objective: Stress may have an important role in the origin and progress of depression and
can impair metabolic homeostasis. The one-carbon cycle (1-CC) metabolism and amino …

Background Low serum cholesterol levels are related to an increased risk of depression and
its serious consequences. However, the effect of central cholesterol on depressive disorder …

Major depression is a heterogeneous psychiatric disorder whose pathophysiology is not
clearly established yet. Some studies have shown that oxidative stress and mitochondrial …

Early life and adulthood stress increase vulnerability for mental illness, and eventually
trigger depression. N-3 polyunsaturated fatty acids (PUFA) have antidepressant effects, but …

Chemotherapy-induced cognitive impairment (CICI) is a common complication associated
with the use of chemotherapeutics. Doxorubicin (DOX) is a reactive oxygen species (ROS) …

Background Aging is a phenomenon that all living organisms surely face. d-galactose (D-
gal) has been used to develop an aging model of brain. Lithium (Li) has been proposed to …

Parkinson's disease (PD) is an idiopathic disease caused by the loss or degeneration of the
dopaminergic (dopamine-producing) neurons in the brain and characterized by various …

Background Chronic unpredictable stressors can produce a situation similar to human
depression and such animal models can be used for the preclinical evaluation of …