The role B cells and humoral immunity play in multiple sclerosis (MS) is continually evolving.
Recent discoveries include advances in lesion classification, identification of B cell clonal …

Results from immunoglobulin-transgenic mice and BCR-mutant mice have been widely
interpreted in recent years as supporting a simple 'activation'model for the origin of CD5+/B …

It has been over 35 years since the discovery of a special subtype of B cells in mice. These
IgM+ B cells are named B-1 cells, whereas conventional B cells are referred to as B-2 cells …

X-linked lymphoproliferative disease (XLP) is a severe immunodeficiency associated with a
marked reduction in circulating memory B cells. Our investigation of the B cell compartment …

Although immature/transitional peripheral B cells may remain susceptible to selection
pressures before full maturation, the nature and timing of these selection events remain …

Over the past two decades B cells have increasingly moved into the spotlight in multiple
sclerosis (MS) research. This interest was fuelled by growing understanding and acceptance …

Publisher Summary This chapter focuses on the human b cell subsets, relates it to
autoimmune disease, and discusses its functions. The chapter correlates them as the cell of …

Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system
with no clear etiology. Until recently, most studies have emphasized the role of T cells in the …

The hematopoietic humanized mouse (hu-mouse) model is a powerful resource to study and
manipulate the human immune system. However, a major and recurrent issue with this …

Highlights•The MHCII antigen presentation pathway has unique features in B cells.•The
MHCII antigen presentation pathway is regulated differently in different B cell subsets.•B cell …