Cellular functions of HPV16 E5 oncoprotein during oncogenic transformation

L Gutierrez-Xicotencatl, A Pedroza-Saavedra… - Molecular Cancer …, 2021 - AACR
The human papillomavirus (HPV) is recognized as the main etiologic agent associated with
cervical cancer. HPVs are epitheliotropic, and the ones that infect the mucous membranes …

Advances in molecular mechanism of HPV16 E5 oncoprotein carcinogenesis

B Chen, L Zhao, R Yang, T Xu - Archives of Biochemistry and Biophysics, 2023 - Elsevier
For a considerable duration, cervical cancer has posed a significant risk to the well-being
and survival of women. The emergence and progression of cervical cancer have garnered …

In vitro biological activities of the E6 and E7 genes vary among human papillomaviruses of different oncogenic potential

MS Barbosa, WC Vass, DR Lowy, JT Schiller - Journal of virology, 1991 - Am Soc Microbiol
Human papillomavirus type 16 (HPV-16) and HPV-18 are often detected in cervical
carcinomas, while HPV-6, although frequently present in benign genital lesions, is only …

Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value

N Ganguly - Cellular oncology, 2012 - Springer
Background Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus.
HPV infection occurs through sexual route, and the virus infects mucosal and cutaneous …

Search for cellular partners of human papillomavirus type 16 E2 protein

AK Olejnik-Schmidt, MT Schmidt, W Kędzia… - Archives of …, 2008 - Springer
Human papillomaviruses (HPVs) are small, double-stranded DNA viruses that infect
cutaneous and mucosal epithelia. Type 16 (HPV16) displays tropism to genital epithelia …

Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment

MK Kim, HS Kim, SH Kim, JM Oh, JY Han… - Biochemical …, 2010 - Elsevier
Human papillomavirus (HPV) infection is considered to be the necessary cause of cervical
cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant …

HPV16 E2 is an immediate early marker of viral infection, preceding E7 expression in precursor structures of cervical carcinoma

Y Xue, S Bellanger, W Zhang, D Lim, J Low, D Lunny… - Cancer research, 2010 - AACR
The viral E2 gene product plays a crucial role in the human papillomavirus (HPV) vegetative
cycle by regulating both transcription and replication of the viral genome. E2 is a …

Human papillomavirus E5 protein, the undercover culprit of tumorigenesis

N Hemmat, HB Baghi - Infectious agents and cancer, 2018 - Springer
Human papillomavirus (HPV) is the most common viral infection of the reproductive tract
worldwide. It has been well documented that the HPV oncoproteins E6 and E7 play …

Human papillomavirus: E6 and E7 oncogenes

G Boulet, C Horvath, DV Broeck, S Sahebali… - The international journal …, 2007 - Elsevier
The recognition of a causal relationship between human papillomaviruses and cancer
almost 30 years ago led to a rapid expansion of knowledge in the field, resulting in the …

New HPV E6 binding proteins: dangerous liaisons?

MHG Kubbutat, KH Vousden - Trends in Microbiology, 1998 - cell.com
(HPVs) are by far the best characterized of the human tumor viruses and, as they contribute
to the development of almost all cervical cancers, represent a major disease worldwide. The …