Therapeutic approaches to amyotrophic lateral sclerosis from the lab to the clinic

VP Chavda, C Patel, D Modh, YN Ertas… - Current Drug …, 2022 - ingentaconnect.com
Amyotrophic Lateral Sclerosis (ALS) is a terminal neuro-degenerative disorder that is
clinically recognized as a gradual degeneration of the upper and lower motor neurons, with …

Current developments in gene therapy for amyotrophic lateral sclerosis

JM Scarrott, S Herranz-Martín, AR Alrafiah… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is a devastating adult neurodegenerative
disorder characterized by motor neuron degeneration and death around 3 years from onset …

Roots to start research in amyotrophic lateral sclerosis: molecular pathways and novel therapeutics for future

D Harikrishnareddy, S Misra, S Upadhyay… - Reviews in the …, 2015 - degruyter.com
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disease that rapidly
progresses from mild motor symptoms to severe motor paralysis and premature death. There …

[HTML][HTML] Recent advances in understanding amyotrophic lateral sclerosis and emerging therapies

LM Gittings, R Sattler - Faculty reviews, 2020 - ncbi.nlm.nih.gov
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that is
characterized by degeneration of both upper and lower motor neurons and subsequent …

New therapeutic targets for amyotrophic lateral sclerosis

M Kuzma-Kozakiewicz, H Kwiecinski - Expert opinion on …, 2011 - Taylor & Francis
Introduction: Amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
disorders, affecting approximately half a million people worldwide. Currently there is no cure …

Translational Therapeutic Str ategies in Amyotrophic Lateral Sclerosis

H Ryu, RJ Ferrante - Mini Reviews in Medicinal Chemistry, 2007 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS) is a clinically severe and fatal neurodegenerative
disease characterized by a loss of both upper and lower motor neurons, resulting in …

Gene therapy for amyotrophic lateral sclerosis

T Federici, NM Boulis - Neurobiology of disease, 2012 - Elsevier
Gene therapy continues to be a potential option for amyotrophic lateral sclerosis (ALS). This
chapter will inform the reader about promising therapeutic transgenes and proof-of-principle …

Recent advances in amyotrophic lateral sclerosis research: perspectives for personalized clinical application

C Benkler, D Offen, E Melamed, L Kupershmidt, T Amit… - EPMA Journal, 2010 - Springer
Abstract Treatment of amyotrophic lateral sclerosis (ALS) has been fueled, in part, by
frustration over the shortcomings of the symptomatic drugs available, since these do not …

Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation

RJ Mead, N Shan, HJ Reiser, F Marshall… - Nature Reviews Drug …, 2023 - nature.com
Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Biomarkers and future targets for development in amyotrophic lateral sclerosis

P Menon, MC Kiernan, S Vucic - Current Medicinal Chemistry, 2014 - ingentaconnect.com
Although the pathophysiological mechanisms underlying the development of amyotrophic
lateral sclerosis (ALS) remain to be fully elucidated, there have been significant advances in …