Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

Objective: This article presents the case that a more rapid, individualized approach to
treating major depressive disorder (MDD) may increase the likelihood of achieving full …

Background: This article analyzed data from the intervention arm of a large treatment trial to
demonstrate the importance of clinical severity, course, comorbidity, and treatment response …

Major Depressive Disorder (MDD) is a prevalent illness that is frequently associated with
significant disability, morbidity and mortality. Despite the development and availability of …

Background Current practice for selecting pharmacological and non-pharmacological
antidepressant treatments has yielded low response and remission rates in Major …

It is increasingly recognised that major depressive disorder can be a chronic condition with
many patients experiencing recurrent episodes. Remission from a depressive episode …

Leading biological hypotheses propose that biological changes may underlie major
depressive disorder onset and relapse/recurrence. Here, we investigate if there is …

Background Depression is commonly perceived as a single underlying disease with a
number of potential treatment options. However, patients with major depression differ …

During the past decade, evidence from research on mood disorders has demonstrated that
remission is the optimal outcome of treatment. However, there continues to be considerable …

Background Limited controlled data exist to guide treatment choices for clinicians caring for
patients with major depressive disorder (MDD). Although many putative predictors of …