The requirement for novel platinum antitumor drugs led to the synthesis of dinuclear
bisplatinum complexes. To understand the molecular mechanisms underlying the biological …

Modifications of natural DNA in a cell‐free medium by dinuclear bisplatinum complexes with
equivalent coordination spheres, represented by the general formula [{trans‐PtCl (NH3) 2} 2 …

Revised Manuscript Received March 11, 1994® abstract: The sequence specificity of
interstrand cross-links induced in DNA by mononuclear and dinuclear platinum complexes …

The novel anticancer drug ([{trans-PtCl (NH3) 2} 2-μ-{trans-Pt (NH3) 2 (NH2 (CH2) 6NH2)
2}](NO3) 4)(BBR3464, 1, 0, 1/t, t, t, TPC) forms a 1, 4-interstrand cross-linked adduct with the …

Polynuclear platinum compounds comprise a unique class of anticancer agents with
chemical and biological properties different from mononuclear platinum drugs. The lead …

The center of it all: An antitumor‐active trinuclear platinum complex forms unprecedented
interstrand cross‐linked triadducts with 18‐mer DNA duplexes (see figure; complex in yellow …

Revised Manuscript Received July 6, 7995® abstract: Recognition and processing by
cellular proteins of DNA modifiedby platinum complexes have been suggested to be …

Abstract Bis (platinum) complexes [{cis-PtCl2 (NH3)} 2H2N (CH2) nNH2] are a novel series
of potential anticancer agents in which two cis-diamine (platinum) groups are linked by an …

The novel phase II anticancer drug BBR3464 ([{trans-PtCl (NH 3) 2} 2-µ-{trans-Pt (NH 3) 2
(NH 2 (CH 2) 6 NH 2) 2}](NO 3) 4) forms a 1, 4-interstrand cross-link adduct with the self …

Polynuclear platinum compounds demonstrate many novel phenomena in their interactions
with DNA and proteins as well as novel anti-cancer activities. Previous studies indicated that …