Sleep disturbance: an early sign of Alzheimer's disease

C He, Z Hu, C Jiang - Neuroscience Bulletin, 2020 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with
cognitive impairment in older adults. The accumulation of insoluble forms of amyloid-b (Ab) …

[HTML][HTML] Sleep in Alzheimer's disease–beyond amyloid

JK Holth, TK Patel, DM Holtzman - Neurobiology of sleep and circadian …, 2017 - Elsevier
Sleep disorders are prevalent in Alzheimer's disease (AD) and a major cause of
institutionalization. Like AD pathology, sleep abnormalities can appear years before …

[HTML][HTML] Mounting Evidence on the Relationship between Sleep and Alzheimer's Disease

L De Gennaro, S Cordone - Journal of Integrative Neuroscience, 2024 - imrpress.com
The relationship between sleep and Alzheimer's disease (AD) has become increasingly
apparent in recent years with the results of new scientific investigations and with AD being …

Sleep and Alzheimer disease pathology—a bidirectional relationship

YES Ju, BP Lucey, DM Holtzman - Nature Reviews Neurology, 2014 - nature.com
Factors other than age and genetics may increase the risk of developing Alzheimer disease
(AD). Accumulation of the amyloid-β (Aβ) peptide in the brain seems to initiate a cascade of …

[HTML][HTML] Sleep disorders associated with Alzheimer's disease: a perspective

A Brzecka, J Leszek, GM Ashraf, M Ejma… - Frontiers in …, 2018 - frontiersin.org
Sleep disturbances, as well as sleep-wake rhythm disturbances, are typical symptoms of
Alzheimer's disease (AD) that may precede the other clinical signs of this neurodegenerative …

Bidirectional relationship between sleep and Alzheimer's disease: role of amyloid, tau, and other factors

C Wang, DM Holtzman - Neuropsychopharmacology, 2020 - nature.com
As we age, we experience changes in our nighttime sleep and daytime wakefulness.
Individuals afflicted with Alzheimer's disease (AD) can develop sleep problems even before …

Sleep disturbances in Alzheimer's and Parkinson's diseases

SM Rothman, MP Mattson - Neuromolecular medicine, 2012 - Springer
Alzheimer's disease (AD) and Parkinson's disease (PD) are the two most common
neurodegenerative disorders and exact a burden on our society greater than cardiovascular …

[HTML][HTML] It's complicated: The relationship between sleep and Alzheimer's disease in humans

BP Lucey - Neurobiology of disease, 2020 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an
asymptomatic period of amyloid-β (Aβ) deposition as insoluble extracellular plaque …

The sleep–wake cycle and Alzheimer's disease: what do we know?

MM Lim, JR Gerstner, DM Holtzman - Neurodegenerative disease …, 2014 - Future Medicine
Sleep–wake disturbances are a highly prevalent and often disabling feature of Alzheimer's
disease (AD). A cardinal feature of AD includes the formation of amyloid plaques, associated …

Beyond the sleep-amyloid interactions in Alzheimer's disease pathogenesis

S Ning, M Jorfi - Journal of neurophysiology, 2019 - journals.physiology.org
Cognitive impairment in older adults is associated with sleep and circadian rhythm
disturbances. Numerous studies have linked disrupted sleep and circadian rhythms with …