The frequent need to obtain an estimate of renal function in cancer patients, not least for
targeting carboplatin dose, has led to a number of approaches to estimate glomerular …

Purpose The glomerular filtration rate (GFR) is essential for carboplatin chemotherapy
dosing; however, the best method to estimate GFR in patients with cancer is unknown. We …

A narrow therapeutic index is a characteristic feature of cytotoxic agents. Some of these
agents are almost entirely eliminated renally in unchanged active form. As a consequence …

Background The aim of this study was to compare measured glomerular filtration rate (GFR)
with estimates of GFR derived from the population pharmacokinetic methods of Martin and …

Background: Carboplatin is used in treating many types of cancer. Because renal excretion
is the major variable determining the pharmacokinetics of this drug, a dosing formula based …

Knowledge of the renal function is important in cancer patients. Prior to the administration of
potentially nephrotoxic agents, careful evaluation of the renal function and, particularly, the …

Abstract Purpose: The Calvert formula is a widely applied algorithm for the a priori dosing of
carboplatin based on patients glomerular filtration rate (GFR) as accurately measured using …

Background: Glomerular filtration rate (GFR) is used in the calculation of carboplatin dose.
Glomerular filtration rate is measured using a radioisotope method (radionuclide GFR …

Carboplatin is a chemotherapeutic agent frequently used in the treatment of various
malignancies. An individual dosing strategy has been recommended to yield the most …

The aim was to compare doses of carboplatin calculated using the Calvert formula and
Chatelut formula and also to compare doses calculated using Calvert formula, modified with …