Genome-wide Transcriptional Characterization of the ETV6-RUNX1-positive Childhood Leukemia
S Teppo - 2020 - trepo.tuni.fi
Acute lymphoblastic leukemia (ALL) is the most common cancer affecting in childhood. It
occurs typically in early B-lineage cells and is characterized by a few specific initiating …
occurs typically in early B-lineage cells and is characterized by a few specific initiating …
[HTML][HTML] Pathogenesis of ETV6/RUNX1-positive childhood acute lymphoblastic leukemia and mechanisms underlying its relapse
C Sun, L Chang, X Zhu - Oncotarget, 2017 - ncbi.nlm.nih.gov
Abstract ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute
lymphoblastic leukemia (ALL). Multiple lines of evidence imply a “two-hit” model for the …
lymphoblastic leukemia (ALL). Multiple lines of evidence imply a “two-hit” model for the …
[HTML][HTML] ETV6–RUNX1 fusion gene and additional genetic changes in infant leukemia: a genome-wide analysis
M Emerenciano, S Bungaro, G Cazzaniga… - Cancer genetics and …, 2009 - Elsevier
Acute lymphoblastic leukemia (ALL) in infants is characterized by a high frequency of MLL
gene rearrangements. By contrast, the t (12; 21) ETV6–RUNX1 fusion gene is typically …
gene rearrangements. By contrast, the t (12; 21) ETV6–RUNX1 fusion gene is typically …
Genome-wide repression of eRNA and target gene loci by the ETV6-RUNX1 fusion in acute leukemia
S Teppo, S Laukkanen, T Liuksiala… - Genome …, 2016 - genome.cshlp.org
Approximately 20%–25% of childhood acute lymphoblastic leukemias carry the ETV6-
RUNX1 (E/R) fusion gene, a fusion of two central hematopoietic transcription factors, ETV6 …
RUNX1 (E/R) fusion gene, a fusion of two central hematopoietic transcription factors, ETV6 …
Sequence of genetic events in ETV6-RUNX1 positive B precursor ALL: insights from identical twins with concordant leukaemia
CM Bateman, SW Horsley, T Chaplin, BD Young… - Blood, 2008 - Elsevier
Monozygotic twin pairs with concordant ALL have provided unique insights into the
molecular pathogenesis and natural history of childhood leukaemia. Data from twin pair …
molecular pathogenesis and natural history of childhood leukaemia. Data from twin pair …
RAG1 co‐expression signature identifies ETV6‐RUNX1‐like B‐cell precursor acute lymphoblastic leukemia in children
D Chen, A Camponeschi, J Nordlund… - Cancer …, 2021 - Wiley Online Library
B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) can be classified into subtypes
according to the genetic aberrations they display. For instance, the translocation t (12; …
according to the genetic aberrations they display. For instance, the translocation t (12; …
A Human iPSC Model Reveals Specific Upregulation of Linker Histone H1-0 in ETV6:: RUNX1+ Preleukemia and B Cell Precursor Acute Lymphoblastic Leukemia
VH Jepsen, D Hein, D Picard, T Lautwein, R Wagener… - Blood, 2022 - ashpublications.org
Abstract The ETV6:: RUNX1 translocation is the most common chromosomal rearrangement
associated with pediatric B cell precursor acute lymphoblastic leukemia (BCP-ALL). As …
associated with pediatric B cell precursor acute lymphoblastic leukemia (BCP-ALL). As …
[PDF][PDF] Novel transcriptional targets of ETV6, a transcription factor frequently altered in childhood pre-B acute lymphoblastic leukemia
C Malouf, K Lagace, C Drullion… - Cancer Sci Open Res …, 2016 - researchgate.net
Abstract Pre-B Acute Lymphoblastic Leukemia (ALL), the most common hematological
malignancy in children, represents~ 25% of all pediatric cancer cases. The most frequent …
malignancy in children, represents~ 25% of all pediatric cancer cases. The most frequent …
The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias
H Lilljebjörn, C Soneson, A Andersson… - Human molecular …, 2010 - academic.oup.com
The ETV6/RUNX1 fusion gene, present in 25% of B-lineage childhood acute lymphoblastic
leukemia (ALL), is thought to represent an initiating event, which requires additional genetic …
leukemia (ALL), is thought to represent an initiating event, which requires additional genetic …
[HTML][HTML] 2% of Healthy Newborns Reveal ETV6-RUNX1 Fusion By Genomic Inverse PCR for Exploration of Ligated Breakpoints (GIPFEL)
D Schaefer, M Olsen, U Lausten-Thomsen, C Schipp… - Blood, 2016 - Elsevier
Pediatric acute lymphoblastic leukemia (ALL) is characterized by preleukemic recurrent
chromosomal translocations that emerge in utero. The translocation t (12; 21) resulting in the …
chromosomal translocations that emerge in utero. The translocation t (12; 21) resulting in the …