This Comment summarises the chemistry and DNA binding of dinuclear platinum-amine, or
bis (platinum), complexes, a new class of potent antitumor agents. In these structures, the Pt …

Dinuclear and trinuclear platinum complexes represent a new class of anticancer agents,
distinct in DNA binding and antitumor activity from their mononuclear counterparts. The first …

Despite the widespread use of antineoplastic platinum drugs, a number of accompanying
disadvantages exist. In connection with attempts to circumvent these problems new platinum …

The center of it all: An antitumor‐active trinuclear platinum complex forms unprecedented
interstrand cross‐linked triadducts with 18‐mer DNA duplexes (see figure; complex in yellow …

Bifunctional binding of platinum complexes to DNA is considered essential for manifestation
of antitumor activity. The studies on [{PtCl (NH 3) 2} 2 H 2 N (CH 2) 4 NH 2] 2+ show that …

This article reviews investigations over the last 15 years into the development of multi-
nuclear platinum complexes as anti-cancer agents, with the purpose of providing an insight …

This paper is a focused review of our recent efforts to produce multi-nuclear platinum anti-
cancer complexes that preferentially target adenine residues in DNA. Multi-nuclear platinum …

Polynuclear platinum compounds comprise a unique class of anticancer agents with
chemical and biological properties different from mononuclear platinum drugs. The lead …

Abstract Bis (platinum) complexes [{cis-PtCl2 (NH3)} 2H2N (CH2) nNH2] are a novel series
of potential anticancer agents in which two cis-diamine (platinum) groups are linked by an …

A series of intercalator-tethered platinum (II) complexes PtLCl2 have been prepared, where
L are the diamine ligands N-[2-[(aminoethyl) amino] ethyl]-phenazine-1-carboxamide, N-[3 …