Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs
A Wang, RVP Ribeiro, A Ali, E Brambate… - Science Translational …, 2022 - science.org
Donor organ allocation is dependent on ABO matching, restricting the opportunity for some
patients to receive a life-saving transplant. The enzymes FpGalNAc deacetylase and …
patients to receive a life-saving transplant. The enzymes FpGalNAc deacetylase and …
Enzymatic conversion of human blood group A kidneys to universal blood group O
S MacMillan, SA Hosgood, L Walker-Panse… - Nature …, 2024 - nature.com
ABO blood group compatibility restrictions present the first barrier to donor-recipient
matching in kidney transplantation. Here, we present the use of two enzymes, Fp GalNAc …
matching in kidney transplantation. Here, we present the use of two enzymes, Fp GalNAc …
Ex vivo perfusion with adenosine A2A receptor agonist enhances rehabilitation of murine donor lungs after circulatory death
ML Stone, AK Sharma, VR Mas, RC Gehrau… - …, 2015 - journals.lww.com
Background Ex vivo lung perfusion (EVLP) enables assessment and rehabilitation of
marginal donor lungs before transplantation. We previously demonstrated that adenosine …
marginal donor lungs before transplantation. We previously demonstrated that adenosine …
Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs
AE Hozain, JD O'Neill, MR Pinezich, Y Tipograf… - Nature medicine, 2020 - nature.com
Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the
use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal …
use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal …
Towards donor lung recovery—gene expression changes during ex vivo lung perfusion of human lungs
JC Yeung, R Zamel, W Klement, XH Bai… - American Journal of …, 2018 - Wiley Online Library
We and others have demonstrated that acellular normothermic ex vivo lung perfusion of high‐
risk donor lungs can result in posttransplant outcomes equivalent to that of …
risk donor lungs can result in posttransplant outcomes equivalent to that of …
Extracorporeal lung perfusion (ex-vivo lung perfusion)
M Cypel, S Keshavjee - Current opinion in organ transplantation, 2016 - journals.lww.com
Extracorporeal lung perfusion (ex-vivo lung perfusion) : Current Opinion in Organ
Transplantation Extracorporeal lung perfusion (ex-vivo lung perfusion) : Current Opinion in …
Transplantation Extracorporeal lung perfusion (ex-vivo lung perfusion) : Current Opinion in …
Successful management of an ABO-mismatched lung allograft using antigen-specific immunoadsorption, complement inhibition, and immunomodulatory therapy1
RN Pierson III, JE Loyd, A Goodwin, D Majors… - …, 2002 - journals.lww.com
Background. Successful management of an ABO-mismatched lung allograft recipient has
not previously been described. Methods. Because of a clerical error, a 67-year-old blood …
not previously been described. Methods. Because of a clerical error, a 67-year-old blood …
Potential therapeutic targets for lung repair during human ex vivo lung perfusion
Introduction The ex vivo lung perfusion (EVLP) technique has been developed to assess the
function of marginal donor lungs and has significantly increased donor lung utilisation. EVLP …
function of marginal donor lungs and has significantly increased donor lung utilisation. EVLP …
α1-Anti-trypsin improves function of porcine donor lungs during ex-vivo lung perfusion
H Lin, M Chen, F Tian, J Tikkanen, L Ding… - The Journal of Heart and …, 2018 - Elsevier
Background Ex-vivo lung perfusion (EVLP), a technique for donor lung assessment, also
represents a platform for donor lung repair and immunomodulation. α 1-Anti-trypsin (A1AT) …
represents a platform for donor lung repair and immunomodulation. α 1-Anti-trypsin (A1AT) …
[HTML][HTML] Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine …
EJ Charles, JH Mehaffey, AK Sharma, Y Zhao… - The Journal of thoracic …, 2017 - Elsevier
Objective The current supply of acceptable donor lungs is not sufficient for the number of
patients awaiting transplantation. We hypothesized that ex vivo lung perfusion (EVLP) with …
patients awaiting transplantation. We hypothesized that ex vivo lung perfusion (EVLP) with …