Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs

A Wang, RVP Ribeiro, A Ali, E Brambate… - Science Translational …, 2022 - science.org
Donor organ allocation is dependent on ABO matching, restricting the opportunity for some
patients to receive a life-saving transplant. The enzymes FpGalNAc deacetylase and …

Enzymatic conversion of human blood group A kidneys to universal blood group O

S MacMillan, SA Hosgood, L Walker-Panse… - Nature …, 2024 - nature.com
ABO blood group compatibility restrictions present the first barrier to donor-recipient
matching in kidney transplantation. Here, we present the use of two enzymes, Fp GalNAc …

Ex vivo perfusion with adenosine A2A receptor agonist enhances rehabilitation of murine donor lungs after circulatory death

ML Stone, AK Sharma, VR Mas, RC Gehrau… - …, 2015 - journals.lww.com
Background Ex vivo lung perfusion (EVLP) enables assessment and rehabilitation of
marginal donor lungs before transplantation. We previously demonstrated that adenosine …

Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs

AE Hozain, JD O'Neill, MR Pinezich, Y Tipograf… - Nature medicine, 2020 - nature.com
Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the
use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal …

Towards donor lung recovery—gene expression changes during ex vivo lung perfusion of human lungs

JC Yeung, R Zamel, W Klement, XH Bai… - American Journal of …, 2018 - Wiley Online Library
We and others have demonstrated that acellular normothermic ex vivo lung perfusion of high‐
risk donor lungs can result in posttransplant outcomes equivalent to that of …

Extracorporeal lung perfusion (ex-vivo lung perfusion)

M Cypel, S Keshavjee - Current opinion in organ transplantation, 2016 - journals.lww.com
Extracorporeal lung perfusion (ex-vivo lung perfusion) : Current Opinion in Organ
Transplantation Extracorporeal lung perfusion (ex-vivo lung perfusion) : Current Opinion in …

Successful management of an ABO-mismatched lung allograft using antigen-specific immunoadsorption, complement inhibition, and immunomodulatory therapy1

RN Pierson III, JE Loyd, A Goodwin, D Majors… - …, 2002 - journals.lww.com
Background. Successful management of an ABO-mismatched lung allograft recipient has
not previously been described. Methods. Because of a clerical error, a 67-year-old blood …

Potential therapeutic targets for lung repair during human ex vivo lung perfusion

A Wong, R Zamel, J Yeung, GD Bader… - European …, 2020 - Eur Respiratory Soc
Introduction The ex vivo lung perfusion (EVLP) technique has been developed to assess the
function of marginal donor lungs and has significantly increased donor lung utilisation. EVLP …

α1-Anti-trypsin improves function of porcine donor lungs during ex-vivo lung perfusion

H Lin, M Chen, F Tian, J Tikkanen, L Ding… - The Journal of Heart and …, 2018 - Elsevier
Background Ex-vivo lung perfusion (EVLP), a technique for donor lung assessment, also
represents a platform for donor lung repair and immunomodulation. α 1-Anti-trypsin (A1AT) …

[HTML][HTML] Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine …

EJ Charles, JH Mehaffey, AK Sharma, Y Zhao… - The Journal of thoracic …, 2017 - Elsevier
Objective The current supply of acceptable donor lungs is not sufficient for the number of
patients awaiting transplantation. We hypothesized that ex vivo lung perfusion (EVLP) with …